Evidence map›Paper›PMID 33517526›Full record

ArticleJournal of autism and developmental disorders2023

Developmental Skills of Individuals with Angelman Syndrome Assessed Using the Bayley-III.

Anjali Sadhwani, Anne Wheeler, Angela Gwaltney, Sarika U Peters, Rene L Barbieri-Welge, Lucia T Horowitz, Lisa M Noll, Rachel J Hundley, Lynne M Bird, Wen-Hann Tan

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 59 citations in OpenAlex.

  1. Delta power robustly predicts cognitive function in Angelman syndrome.Annals of clinical and translational neurology · 2021
    Trial
  2. Caregiver Meaningful Score Differences and Meaningful Score Regions for the Observer-Reported Communication Ability Measure for Individuals with Angelman Syndrome.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Prelinguistic Communication Complexity of Children With Neurogenetic Syndromes.Journal of speech, language, and hearing research : JSLHR · 2025
    Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  17. Article
  18. Article
  19. Clinical trials for Lennox-Gastaut syndrome: Challenges and priorities.Annals of clinical and translational neurology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Anjali Sadhwani *Department of Psychiatry, Boston Children's Hospital, Boston, MA, 02115, USA. Anjali.sadhwani@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-0938-0591
Anne Wheeler *RTI International, Research Triangle Park, NC, USA.
Angela GwaltneyRTI International, Research Triangle Park, NC, USA.
Sarika U PetersDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Rene L Barbieri-WelgeDevelopmental Evaluation Clinic, Rady Children's Hospital - San Diego, San Diego, CA, USA.
Lucia T HorowitzGreenwood Genetic Center, Greenwood, SC, USA.
Lisa M NollPsychology Service, Texas Children's Hospital, Houston, TX, USA.
Rachel J HundleyDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Lynne M Bird *Division of Dysmorphology/Genetics, Rady Children's Hospital - San Diego, San Diego, CA, USA.
Wen-Hann Tan *Harvard Medical School, Boston, MA, USA.
Boston Children's Hospital · USRTI International · USVanderbilt University Medical Center · USBaylor College of Medicine · USGreenwood Genetic Center · USRady Children's Hospital-San Diego · USUniversity of California San Diego · US

Funding

Training and Career Development ComponentU54HD061222 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PERCY, ALAN KENNETH · 2009 to 2019
$12.4M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
RARE DISEASE CRC FOR NEW THERAPIES AND NEW DIAGNOSTICSU54RR019478 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L. · 2003 to 2008
$7.3M
National Institute of Child Health and Human Development U54 HD061222National Institutes of Health U54 RR019478NCRR NIH HHS U54 RR019478NICHD NIH HHS P50 HD103537NICHD NIH HHS U54 HD061222NIH HHS U54 RR019478
6 · The paper itself

Abstract

We describe the development of 236 children with Angelman syndrome (AS) using the Bayley Scales of Infant and Toddler Development, Third Edition. Multilevel linear mixed modeling approaches were used to explore differences between molecular subtypes and over time. Individuals with AS continue to make slow gains in development through at least age 12 years of age at about 1-2 months/year based on age equivalent score and 1-16 growth score points/year depending on molecular subtype and domain. Children with a deletion have lower scores at baseline and slower rate of gaining skills while children with UBE3A variant subtype demonstrated higher scores as well as greater rates of skill attainment in all domains. The developmental profiles of UPD and ImpD were similar.

Indexed as

Angelman SyndromeAutism Spectrum DisorderChildChild DevelopmentDevelopmental DisabilitiesHumansInfantMotor SkillsChild developmentDevelopmental disabilitiesLanguage development disordersMotor skills disordersNeurodevelopmental disorders

Identifiers

PMID33517526
PMCPMC8322148
OpenAlexW3126456244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.