Evidence map›Paper›PMID 33517327›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Addition of

David L Bushnell, Kellie L Bodeker, Thomas M O'Dorisio, Mark T Madsen, Yusuf Menda, Stephen Graves, Gideon K D Zamba, M Sue O'Dorisio

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Response to targeted radionuclide therapy with [Frontiers in endocrinology · 2022
    Pooled it
  3. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  4. Molecular radiotherapy for adult type metastatic neuroendocrine tumours in children.European journal of nuclear medicine and molecular imaging · 2025
    Observational
  5. Review
  6. Review
  7. Review
  8. Review
  9. Use of imaging-based dosimetry for personalising radiopharmaceutical therapy of cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Review
  10. Article
  11. [Frontiers in endocrinology · 2022
    Observational
  12. Combination Therapies with PRRT.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

David L BushnellDivision of Nuclear Medicine, Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, Iowa; david-bushnell@iowa.edu.
Kellie L BodekerDivision of Nuclear Medicine, Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Thomas M O'DorisioDivision of Endocrinology, Department of Internal Medicine, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Mark T MadsenDivision of Nuclear Medicine, Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Yusuf MendaDivision of Nuclear Medicine, Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Stephen GravesDivision of Nuclear Medicine, Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Gideon K D ZambaDepartment of Biostatistics, University of Iowa Hospital and Clinics, Iowa City, Iowa; and.
M Sue O'DorisioDepartment of Pediatrics, University of Iowa Hospital and Clinics, Iowa City, Iowa.
University of Iowa Hospitals and Clinics · USIowa City VA Health Care System · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Project 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI ODORISIO, THOMAS · 2015 to 2021
$13.2M
NCI NIH HHS P50 CA174521
6 · The paper itself

Abstract

Peptide receptor radionuclide therapy (PRRT) is an effective treatment for metastatic neuroendocrine tumors. Delivering a sufficient tumor radiation dose remains challenging because of critical-organ dose limitations. Adding

Indexed as

3-IodobenzylguanidineNeuroendocrine TumorsOctreotidePrecision MedicineAdultAgedFemaleHumansIodine RadioisotopesMaleMiddle AgedOrganometallic CompoundsRadiometryRadiopharmaceuticalsReceptors, PeptideTreatment Outcome3-Iodobenzylguanidine90Y-octreotide, DOTA-Tyr(3)-Iodine-131Iodine RadioisotopesOctreotideOrganometallic CompoundsRadiopharmaceuticalsReceptors, PeptideDOTATOCMIBGpersonalized dosimetryPRRT

Identifiers

PMID33517327
PMCPMC8882893
OpenAlexW3128544049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.