ArticleThe American journal of pathology2021
Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation.
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Article in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 85 citations in OpenAlex.
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Authors and funding
19 authors at 3 institutions in 1 country.
Faith D IhekweazuDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas; Section of Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Houston, Texas. Electronic address: usa.faith.ihekweazu@bcm.edu.
Melinda A EngevikDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Wenly RuanDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas; Section of Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Houston, Texas.
Zhongcheng ShiDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Robert FultzDepartment of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas.
Kristen A EngevikDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.
Alexandra L Chang-GrahamDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.
Jasmin FreebornDivision of Gastroenterology, Department of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas.
Evelyn S ParkDivision of Gastroenterology, Department of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas.
Susan VenableDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Thomas D HorvathDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Sigmund J HaidacherDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Anthony M HaagDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Annie GoodwinDepartment of Pediatrics, The University of Texas Medical Branch at Galveston, Galveston, Texas.
Deborah A SchadyDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Joseph M HyserDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.
Jennifer K SpinlerDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Yuying LiuDivision of Gastroenterology, Department of Pediatrics, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas.
James VersalovicDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · USThe University of Texas Medical Branch at Galveston · US
Funding
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3MProteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8MResearch Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4MTraining Supplement in Enteric Virus Exploitation of Calcium SignalingR01DK115507 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Joseph M. Hyser · 2018 to 2026
$5.0MGut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8MIdentifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612kRegulation of secretory diarrhea by ER-PM junction signalingF30DK112563 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHANG-GRAHAM, ALEXANDRA · 2017 to 2019
$128kNCI NIH HHS U01 CA170930NIDDK NIH HHS F30 DK112563NIDDK NIH HHS K01 DK123195NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK115507NIDDK NIH HHS T32 DK007664
Abstract
The intestinal microbiota influences the development and function of the mucosal immune system. However, the exact mechanisms by which commensal microbes modulate immunity is not clear. We previously demonstrated that commensal Bacteroides ovatus ATCC 8384 reduces mucosal inflammation. Herein, we aimed to identify immunomodulatory pathways employed by B. ovatus. In germ-free mice, mono-association with B. ovatus shifted the CD11b
Indexed as
AnimalsBacteroidesColitisColonCytokinesDextran SulfateHumansInflammationInterleukin-22InterleukinsIntestinal MucosaIntestinesMiceTrinitrobenzenesulfonic AcidCytokinesDextran SulfateInterleukin-22InterleukinsTrinitrobenzenesulfonic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.