Evidence map›Paper›PMID 33516594›Full record

ArticleTrends in microbiology2021

Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence.

Susana K Checa, Germán F Giri, Martín Espariz, José M Argüello, Fernando C Soncini

Open access · greenAbstract read
In one paragraph

Article in Trends in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. CuiT is a Cu importer required for metal homeostasis inBiochemistry and biophysics reports · 2026
    Article
  3. Dual regulation ofmicroLife · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Unique underlying principles shaping copper homeostasis networks.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Review
  10. Evolution of Copper Homeostasis and Virulence inFrontiers in microbiology · 2022
    Article
  11. Advances in Understanding of the Copper Homeostasis inInternational journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Susana K ChecaInstituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, Rosario, Argentina. Electronic address: checa@ibr-conicet.gov.ar.
Germán F GiriInstituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, Rosario, Argentina.
Martín EsparizInstituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, Rosario, Argentina.
José M ArgüelloDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA.
Fernando C SonciniInstituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, Rosario, Argentina. Electronic address: soncini@ibr-conicet.gov.ar.
Instituto de Biología Molecular y Celular de Rosario · ARNational University of Rosario · ARWorcester Polytechnic Institute · US

Funding

Molecular determinants of Salmonella cell-envelope copper homeostasisR01AI150784 · NIAID · WORCESTER POLYTECHNIC INSTITUTE · PI ARGUELLO, JOSE M · 2021 to 2024
$1.7M
Copper homeostasis in the opportunistic pathogen pseudomonas aeruginosaR01GM114949 · NIGMS · WORCESTER POLYTECHNIC INSTITUTE · PI ARGUELLO, JOSE M, LAUBENBACHER, REINHARD · 2015 to 2018
$1.3M
NIAID NIH HHS R01 AI150784NIGMS NIH HHS R01 GM114949
6 · The paper itself

Abstract

Copper (Cu) plays a key role at the host-pathogen interface as both an essential element and a toxic element. Intracellular strains of pathogenic Salmonella have acquired the periplasmic Cu chaperone, CueP, and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Coregulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection.

Indexed as

Host-Pathogen InteractionsAnimalsBacterial ProteinsCell MembraneCopperHumansOxidation-ReductionPeriplasmSalmonella typhimuriumVirulenceBacterial ProteinsCopperbacterial envelopecopperCueP and Cusenteropathogenshost–pathogen interaction

Identifiers

PMID33516594
PMCPMC9185223
OpenAlexW3124129091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.