Evidence map›Paper›PMID 33516259›Full record

ArticleJournal of neuroinflammation2021

Changes of blood-brain-barrier function and transfer of amyloid beta in rats with collagen-induced arthritis.

Po-Hsuan Lai, Ting-Hsuan Wang, Nai-You Zhang, Kuo-Chen Wu, Chung-Chen Jane Yao, Chun-Jung Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  7. Peripheral proteinopathy in neurodegenerative diseases.Translational neurodegeneration · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Po-Hsuan LaiSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan.
Ting-Hsuan WangSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan.
Nai-You ZhangSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan.
Kuo-Chen WuSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan.
Chung-Chen Jane YaoGraduate Institute of Clinical Dentistry, Dental School, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chun-Jung LinSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen South Road, Taipei, Taiwan. clementumich@ntu.edu.tw.ORCID http://orcid.org/0000-0001-9220-3507
National Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST106-2320-B-002-007-MY3
6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is characterized by synovial inflammation, cartilage damage, and systemic inflammation. RA is also associated with the occurrence of neuroinflammation and neurodegenerative diseases. In this study, the impacts of RA on the function of the blood-brain barrier (BBB) and the disposition of amyloid beta (Aβ), including BBB transport and peripheral clearance of Aβ, were investigated in rats with collagen-induced arthritis (CIA), an animal model with similarity to clinical and pathological features of human RA.

methodsCIA was induced in female Lewis rats. In addition to neuroinflammation, the integrity and function of the BBB were examined. The expression of Aβ-transporting proteins at brain blood vessels was measured. Blood-to-brain influx and plasma clearance of Aβ were determined.

resultsBoth microgliosis and astrogliosis were significantly increased in the brain of CIA rats, compared with controls. In terms of BBB function, the BBB permeability of sodium fluorescein, a marker compound for BBB integrity, was significantly increased in CIA rats. Moreover, increased expression of matrix metalloproteinase-3 (MMP-3) and MMP-9 and decreased expression of tight junction proteins, zonula occludens-1 (ZO-1) and occludin, were observed in brain microvessels of CIA rats. In related to BBB transport of Aβ, protein expression of the receptor of advanced glycation end product (RAGE) and P-glycoprotein (P-gp) was significantly increased in brain microvessels of CIA rats. Notably, much higher expression of RAGE was identified at the arterioles of the hippocampus of CIA rats. Following an intravenous injection of human Aβ, significant higher brain influx of Aβ was observed in the hippocampus of CIA rats.

conclusionsNeuroinflammation and the changes of BBB function were observed in CIA rats. The increased RAGE expression at cerebral blood vessels and enhanced blood-to-brain influx of Aβ indicate the imbalanced BBB clearance of Aβ in RA.

Indexed as

Amyloid beta-PeptidesAnimalsArthritis, ExperimentalBlood-Brain BarrierBrainFemaleMetabolic Clearance RateMicrovesselsPeptide FragmentsRatsRats, Inbred LewReceptor for Advanced Glycation End ProductsAger protein, ratAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentsReceptor for Advanced Glycation End ProductsAmyloid betaBlood-brain barrierCollagen-induced arthritisP-glycoproteinReceptor of advanced glycation end product

Identifiers

PMID33516259
PMCPMC7847579
OpenAlexW3127744380

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.