ArticleJournal of affective disorders2021
Multiple domains of risk factors for first onset of depression in adolescent girls.
Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Stressful life events and depression onset: A longitudinal investigation of depression course subtypes.Journal of psychopathology and clinical science · 2026Article
- Age matters: a narrative review and machine learning analysis on shared and separate multidimensional risk domains for early and late onset suicidal behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Reactivity to Interpersonal Conflict: A Correlate of Non-Remission in Childhood Depression-Evidence Across Modalities and Time Scales.Depression and anxiety · 2026Article
- The interplay of reward responsiveness and socioeconomic disadvantage in the prospective prediction of depression symptoms in youth.Psychological medicine · 2025Article
- How Observed Personality Traits in (Mildly) Depressed Adolescents Relate to Nonverbal Responses of Peers.Child psychiatry and human development · 2025Article
- Intergenerational transmission of depression: Testing a comprehensive set of putative mediators.Journal of psychopathology and clinical science · 2025Article
- Neuromelanin-Sensitive MRI Contrast and Chronic Depression in Young Women.JAMA network open · 2025Article
- Adverse childhood experiences and internalizing symptoms: the moderating role of neural responses to threat.Neurobiology of stress · 2025Article
- Personality and presentation of depression symptoms: A preliminary examination of the pathoplasticity model.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- [Research advances in reward positivity and internalizing and externalizing problems in children and adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Prevalence and determinants of mental health problems experienced by school-going adolescents in Sri Lanka.Global mental health (Cambridge, England) · 2025Article
- Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women.The American journal of psychiatry · 2024Article
- The Prospective Predictive Power of Parent-Reported Personality Traits and Facets in First-Onset Depression in Adolescent Girls.Research on child and adolescent psychopathology · 2024Article
- Moving from Marker to Mechanism using Translational Neurophysiology. A Commentary on Kehrer et al. (2024).Cognitive, affective & behavioral neuroscience · 2024Article
- Physical Activity Is Associated with the Incidence of Depression in United States Adults from the NHANES 2013-18: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Neural reward responsiveness and daily positive affect functioning in adolescent girls.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders.Molecular psychiatry · 2023Observational
- Characterizing positive and negative valence systems function in adolescent depression: An RDoC-informed approach integrating multiple neural measures.Journal of mood and anxiety disorders · 2023Article
- Longitudinal Stability and Interrelations of Tonic and Phasic Irritability in Adolescent Girls.Research on child and adolescent psychopathology · 2023Article
- Preonset predictors of chronic-intermittent depression from early adolescence to early adulthood.Journal of psychopathology and clinical science · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFirst onsets of depression are especially common in adolescent females and often develop into chronic/recurrent illness. Surprisingly few studies have comprehensively evaluated multiple domains of etiologically-informative risk factors for first onset in adolescents from the community. We investigated whether clinical, cognitive, personality, interpersonal, and biological risk factors prospectively predict a first onset of depressive disorder (DD), and of DD with a chronic/recurrent course, in a community sample of adolescent girls.
methods479 girls (13.5-15.5 years) with no history of DD completed baseline assessments of risk factors and five diagnostic assessments over 3 years. Baseline measures were analyzed separately and jointly to prospectively predict first-onset DD and first-onset chronic/recurrent DD.
resultsMost risk factors predicted first-onset DD (n = 93), including depressive symptoms, anxiety disorders, rumination, personality traits, blunted neural response (late positive potential [LPP]) to unpleasant pictures, peer victimization, parental criticism, and parental mood disorder. Depressive symptoms, rumination, parental mood disorder, and parental criticism were independently associated with first onsets. Nearly all measures, including a blunted neural response to rewards (reward positivity [RewP]), also predicted first-onset chronic/recurrent DD (n = 52), with depressive symptoms, low extraversion, poor peer relationships, and blunted RewP emerging as independent risk factors. LIMITATIONS: This study focused on adolescent females and therefore does not provide information on males.
conclusionsMultiple domains of risk factors in early adolescence are prospectively associated with first-onset DD and chronic/recurrent DD. A smaller subset of risk factors uniquely contributing to first onsets may represent core vulnerabilities for adolescent-onset depression and promising prevention targets.
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