Evidence map›Paper›PMID 33515902›Full record

ArticleJournal of biomechanics2021

Manifold learning based data-driven modeling for soft biological tissues.

Qizhi He, Devin W Laurence, Chung-Hao Lee, Jiun-Shyan Chen

Abstract read
In one paragraph

Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Disentangled Representation Learning for Parametric Partial Differential Equations.... International Conference on Learning Representations · 2026
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  6. MetaNO: How to Transfer Your Knowledge on Learning Hidden Physics.Computer methods in applied mechanics and engineering · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qizhi HeDepartment of Structural Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Devin W LaurenceBiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USA.
Chung-Hao LeeBiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USA; Institute for Biomedical Engineering, Science and Technology, The University of Oklahoma, Norman, OK 73019, USA.
Jiun-Shyan ChenDepartment of Structural Engineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: js-chen@ucsd.edu.

Funding

Role of the Extracellular Matrix in Age-Associated Strength Loss: Combining Imaging and Biochemistry to create a Multi-Scale Mesh-free ModelR01AG056999 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SINHA, SHANTANU · 2018 to 2022
$3.1M
American Heart Association-American Stroke Association 16SDG27760143NIA NIH HHS R01 AG056999
6 · The paper itself

Abstract

Data-driven modeling directly utilizes experimental data with machine learning techniques to predict a material's response without the necessity of using phenomenological constitutive models. Although data-driven modeling presents a promising new approach, it has yet to be extended to the modeling of large-deformation biological tissues. Herein, we extend our recent local convexity data-driven (LCDD) framework (He and Chen, 2020) to model the mechanical response of a porcine heart mitral valve posterior leaflet. The predictability of the LCDD framework by using various combinations of biaxial and pure shear training protocols are investigated, and its effectiveness is compared with a full structural, phenomenological model modified from Zhang et al. (2016) and a continuum phenomenological Fung-type model (Tong and Fung, 1976). We show that the predictivity of the proposed LCDD nonlinear solver is generally less sensitive to the type of loading protocols (biaxial and pure shear) used in the data set, while more sensitive to the insufficient coverage of the experimental data when compared to the predictivity of the two selected phenomenological models. While no pre-defined functional form in the material model is necessary in LCDD, this study reinstates the importance of having sufficiently rich data coverage in the date-driven and machine learning type of approaches. It is also shown that the proposed LCDD method is an enhancement over the earlier distance-minimization data-driven (DMDD) against noisy data. This study demonstrates that when sufficient data is available, data-driven computing can be an alternative method for modeling complex biological materials.

Indexed as

Heart Valve ProsthesisMitral ValveAnimalsMachine LearningMaleModels, BiologicalStress, MechanicalSwineData-driven material modelingHyperelasticityLocal convexity data-driven methodManifold learningMitral heart valve

Identifiers

PMID33515902
PMCPMC8101698

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.