Evidence map›Paper›PMID 33515712›Full record

ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2021

Machine learning predictive model for severe COVID-19.

Jianhong Kang, Ting Chen, Honghe Luo, Yifeng Luo, Guipeng Du, Mia Jiming-Yang

Erratum issuedAbstract read
In one paragraph

Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jianhong KangDepartment of Thoracic Surgery, First Affiliated Hospital, Sun-Yat-sen University, Guangzhou, China. Electronic address: 294441422@qq.com.
Ting ChenChengdu Medical College, Chengdu, China. Electronic address: ggcfcmdxdynyzq@gmail.com.
Honghe LuoDepartment of Thoracic Surgery, First Affiliated Hospital, Sun-Yat-sen University, Guangzhou, China. Electronic address: luohhzm@163.com.
Yifeng LuoDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital, Sun‑Yat-sen University, Guangzhou, China. Electronic address: lyif@mail.sysu.edu.cn.
Guipeng DuDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), Chengdu, China.
Mia Jiming-YangMedicine Campus Oberfranken, University of Bayreuth, Bavaria, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop a modified predictive model for severe COVID-19 in people infected with Sars-Cov-2. We developed the predictive model for severe patients of COVID-19 based on the clinical date from the Tumor Center of Union Hospital affiliated with Tongji Medical College, China. A total of 151 cases from Jan. 26 to Mar. 20, 2020, were included. Then we followed 5 steps to predict and evaluate the model: data preprocessing, data splitting, feature selection, model building, prevention of overfitting, and Evaluation, and combined with artificial neural network algorithms. We processed the results in the 5 steps. In feature selection, ALB showed a strong negative correlation (r = 0.771, P < 0.001) whereas GLB (r = 0.661, P < 0.001) and BUN (r = 0.714, P < 0.001) showed a strong positive correlation with severity of COVID-19. TensorFlow was subsequently applied to develop a neural network model. The model achieved good prediction performance, with an area under the curve value of 0.953(0.889-0.982). Our results showed its outstanding performance in prediction. GLB and BUN may be two risk factors for severe COVID-19. Our findings could be of great benefit in the future treatment of patients with COVID-19 and will help to improve the quality of care in the long term. This model has great significance to rationalize early clinical interventions and improve the cure rate.

Indexed as

Machine LearningModels, TheoreticalSARS-CoV-2AdolescentAdultAgedAged, 80 and overAlgorithmsBiomarkersCOVID-19Databases, FactualFemaleHumansMaleMiddle AgedPrognosisBiomarkersMachine learningPredictive modelSevere COVID-19

Identifiers

PMID33515712
PMCPMC7840410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.