Evidence map›Paper›PMID 33515638›Full record

ArticleResuscitation2021

In-hospital cardiac arrest in patients with coronavirus 2019.

Oscar J L Mitchell, Eugene Yuriditsky, Nicholas J Johnson, Olivia Doran, David G Buckler, Stacie Neefe, Raghu R Seethala, Sergey Motov, Ari Moskowitz, Jarone Lee and 5 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Resuscitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. COVID-19 Vaccination and Mental Stress within Diverse Sociodemographic Groups.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Oscar J L MitchellPulmonary, Allergy, and Critical Care Division, University of Pennsylvania, United States; Center for Resuscitation Science, University of Pennsylvania, United States. Electronic address: oscar.mitchell@pennmedicine.upenn.edu.
Eugene YuriditskyDivision of Cardiology, NYU Langone Health, United States.
Nicholas J JohnsonDepartment of Emergency Medicine and Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, United States.
Olivia DoranCenter for Resuscitation Science, University of Pennsylvania, United States.
David G BucklerCenter for Emergency Care Policy and Research, University of Pennsylvania, United States.
Stacie NeefePulmonary, Allergy, and Critical Care Division, University of Pennsylvania, United States.
Raghu R SeethalaDivision of Emergency Critical Care Medicine, Brigham and Women's Hospital, United States.
Sergey MotovDepartment of Emergency Medicine, Maimonides Medical Center, United States.
Ari MoskowitzDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, United States.
Jarone LeeDepartment of Critical Care and Emergency Medicine, Massachusetts General Hospital, United States.
Kelly M GriffinDepartment of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, United States.
Michael G S ShashatyPulmonary, Allergy, and Critical Care Division, University of Pennsylvania, United States; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, United States; Department of Emergency Medicine, University of Pennsylvania, United States.
James M HorowitzDivision of Cardiology, NYU Langone Health, United States.
Benjamin S AbellaCenter for Resuscitation Science, University of Pennsylvania, United States; Department of Emergency Medicine, University of Pennsylvania, United States.
Coronavirus 2019 In-Hospital Cardiac Arrest (COVID IHCA) Study Group
Pulmonary and Allergy Associates · USUniversity of Pennsylvania · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USMaimonides Medical Center · USMassachusetts General Hospital · USNewYork–Presbyterian Hospital · USUniversity of Washington · US

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
The influence of ward capacity strain on outcomes among survivors of acute respiratory failureK23HL146894 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KOHN, RACHEL · 2019 to 2023
$1.0M
NHLBI NIH HHS K23 HL146894NHLBI NIH HHS T32 HL007891
6 · The paper itself

Abstract

backgroundCoronavirus Disease 2019 (COVID-19) has caused over 1 200 000 deaths worldwide as of November 2020. However, little is known about the clinical outcomes among hospitalized patients with active COVID-19 after in-hospital cardiac arrest (IHCA).

aimWe aimed to characterize outcomes from IHCA in patients with COVID-19 and to identify patient- and hospital-level variables associated with 30-day survival.

methodsWe conducted a multicentre retrospective cohort study across 11 academic medical centres in the U.S. Adult patients who received cardiopulmonary resuscitation and/or defibrillation for IHCA between March 1, 2020 and May 31, 2020 who had a documented positive test for Severe Acute Respiratory Syndrome Coronavirus 2 were included. The primary outcome was 30-day survival after IHCA.

resultsThere were 260 IHCAs among COVID-19 patients during the study period. The median age was 69 years (interquartile range 60-77), 71.5% were male, 49.6% were White, 16.9% were Black, and 16.2% were Hispanic. The most common presenting rhythms were pulseless electrical activity (45.0%) and asystole (44.6%). ROSC occurred in 58 patients (22.3%), 31 (11.9%) survived to hospital discharge, and 32 (12.3%) survived to 30 days. Rates of ROSC and 30-day survival in the two hospitals with the highest volume of IHCA over the study period compared to the remaining hospitals were considerably lower (10.8% vs. 64.3% and 5.9% vs. 35.7% respectively, p < 0.001 for both).

conclusionsWe found rates of ROSC and 30-day survival of 22.3% and 12.3% respectively. There were large variations in centre-level outcomes, which may explain the poor survival in prior studies.

Indexed as

HospitalizationAgedCOVID-19FemaleHeart ArrestHumansMaleMiddle AgedRetrospective StudiesSurvival RateUnited StatesCohort studyCOVID-19In-hospital cardiac arrest

Identifiers

PMID33515638
PMCPMC7839632
OpenAlexW3123439084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.