Evidence map›Paper›PMID 33515576›Full record

ArticleDevelopmental biology2021

Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.

Vidisha Mohad, Vlasta Lungova, Jamie Verheyden, Susan L Thibeault

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vidisha MohadDepartment of Surgery, University of Wisconsin-Madison, 5118 WIMR, 1111 Highland Avenue, Madison, WI, 53705, USA. Electronic address: mohad@surgery.wisc.edu.
Vlasta LungovaDepartment of Surgery, University of Wisconsin-Madison, 5118 WIMR, 1111 Highland Avenue, Madison, WI, 53705, USA. Electronic address: lungova@surgery.wisc.edu.
Jamie VerheydenDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, CMME Rm 1087D La Jolla, CA, 92093, USA. Electronic address: jverheyden@health.ucsd.edu.
Susan L ThibeaultDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, 5103 WIMR, 1111 Highland Avenue, Madison, WI, 53705, USA. Electronic address: thibeault@surgery.wisc.edu.
University of Wisconsin–Madison · USUniversity of California San Diego · US

Funding

Engineering the Vocal Fold MucosaR01DC004336 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2000 to 2026
$14.6M
Mechanisms of innate immune-microbial interactions in vocal fold InflammationR01DC012773 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI THIBEAULT, SUSAN LYNN · 2013 to 2022
$4.5M
NIDCD NIH HHS R01 DC004336NIDCD NIH HHS R01 DC012773
6 · The paper itself

Abstract

Proliferation and differentiation of vocal fold epithelial cells during embryonic development is poorly understood. We examined the role of Hippo signaling, a vital pathway known for regulating organ size, in murine laryngeal development. Conditional inactivation of the Hippo kinase genes Lats1 and Lats2, specifically in vocal fold epithelial cells, resulted in severe morphogenetic defects. Deletion of Lats1 and Lats2 caused abnormalities in epithelial differentiation, epithelial lamina separation, cellular adhesion, basement membrane organization with secondary failed cartilage, and laryngeal muscle development. Further, Lats1 and Lats2 inactivation led to failure in differentiation of p63+ basal progenitors. Our results reveal novel roles of Hippo-Lats-YAP signaling in proper regulation of VF epithelial fate and larynx morphogenesis.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell DifferentiationCell ProliferationEpithelial CellsEpitheliumFemaleHippo Signaling PathwayLarynxMaleMiceMice, Inbred C57BLMorphogenesisProtein Serine-Threonine KinasesSignal TransductionAdaptor Proteins, Signal TransducingCell Cycle ProteinsLats1 protein, mouseLATS2 protein, mouseProtein Serine-Threonine KinasesTranscription FactorsTumor Suppressor ProteinsYap1 protein, mouseYAP-Signaling ProteinsEpithelial progenitorsHippoLarynxLat 1Lats2YAP

Identifiers

PMID33515576
PMCPMC7987763
OpenAlexW3123456870

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.