ArticleThe Journal of pediatrics2021
Early Versus Late Brain Magnetic Resonance Imaging after Neonatal Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Therapeutic hypothermia in newborns: evidence-based guidelines from a systematic review.Italian journal of pediatrics · 2026Pooled it
- How well does neonatal neuroimaging correlate with neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy?Pediatric research · 2023Trial
- MRI and proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy: a comprehensive imaging review.Japanese journal of radiology · 2026Review
- Development of a prediction model for mortality in infants undergoing therapeutic hypothermia for neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal encephalopathy due to suspected hypoxic-ischaemic encephalopathy.World journal of pediatrics : WJP · 2025Article
- Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy.Scientific reports · 2025Article
- Automated Neuroprognostication Via Machine Learning in Neonates with Hypoxic-Ischemic Encephalopathy.Annals of neurology · 2025Article
- The predictive value of MRI scores for neurodevelopmental outcome in infants with neonatal encephalopathy.Pediatric research · 2025Article
- MRI scoring systems for long-term outcome prediction in Neonatal Encephalopathy due to hypoxia-ischemia: in search of the crystal ball.Pediatric research · 2025Article
- Insights from serial magnetic resonance imaging in neonatal encephalopathy in term infants.Pediatric research · 2024Article
- MRI predictors of long-term outcomes of neonatal hypoxic ischaemic encephalopathy: a primer for radiologists.The British journal of radiology · 2024Review
- Clinical characteristics of cystic encephalomalacia in children.Frontiers in pediatrics · 2024Article
- Do we need a brain MRI once or twice in infants treated with hypothermia?Pediatric research · 2023Article
- Differences between early and late MRI in infants with neonatal encephalopathy following therapeutic hypothermia.Pediatric research · 2023Article
- Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns.Children (Basel, Switzerland) · 2023Article
- Discussing brain magnetic resonance imaging results for neonates with hypoxic-ischemic encephalopathy treated with hypothermia: A challenge for clinicians and parents.eNeurologicalSci · 2022Article
- Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy.Diagnostics (Basel, Switzerland) · 2022Review
- Application Effect Analysis of Clinical Nursing Pathway in the Care of Neonatal Hypoxic-Ischemic Encephalopathy.Computational and mathematical methods in medicine · 2022Article
- Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the agreement in brain injury findings between early and late magnetic resonance imaging (MRI) in newborn infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and to compare the ability of early vs late MRI to predict early neurodevelopmental outcomes. STUDY
designThis was a prospective longitudinal study of 49 patients with hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia and had MRI performed at both <7 and ≥7 days of age. MRIs were reviewed by an experienced neuroradiologist and assigned brain injury severity scores according to established systems. Scores for early and late MRIs were assessed for agreement using the kappa statistic. The ability of early and late MRI scores to predict death or developmental delay at 15-30 months of age was assessed by logistic regression analyses.
resultsAgreement between the early and late MRI was substantial to near perfect (k > 0.75, P < .001) across MRI scoring systems. In cases of discrepant scoring, early MRI was more likely to identify severe injury when compared with late MRI. Early MRI scores were more consistently predictive of adverse outcomes compared with late MRI.
conclusionsThe results of this study suggest that a single MRI performed in the first week after birth is adequate to assess brain injury and offer prognostic information in this high-risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.