Evidence map›Paper›PMID 33515378›Full record

Trial reportDigestive diseases and sciences2022

Irrigating Acetic Acid Solution During Colonoscopy for the Detection of Sessile Serrated Neoplasia: A Randomized Controlled Trial.

George Tribonias, Angeliki Theodoropoulou, Konstantinos Stylianou, Ioannis Giotis, Afroditi Mpitouli, Dimitrios Moschovis, Yoriaki Komeda, Margarita-Eleni Manola, Gregorios Paspatis, Maria Tzouvala

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Endoscopic Assessment and Management of Colorectal Serrated Lesions: Current Comparative Practice, Challenges, and Future Directions.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

George TriboniasGastroenterology Department, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Mantouvalou D. 3, 18454, Athens, Greece. g.tribonias@gmail.com.
Angeliki TheodoropoulouGastroenterology Department, General Hospital of Heraklion "Venizeleio - Pananeio", Crete, Greece.
Konstantinos StylianouNephrology Department, School of Medicine, University of Crete, Crete, Greece.
Ioannis GiotisGastroenterology Department, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Mantouvalou D. 3, 18454, Athens, Greece.
Afroditi MpitouliGastroenterology Department, General Hospital of Heraklion "Venizeleio - Pananeio", Crete, Greece.
Dimitrios MoschovisGastroenterology Department, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Mantouvalou D. 3, 18454, Athens, Greece.
Yoriaki KomedaGastroenterology Department, Kindai University Hospital, Osaka, Japan.
Margarita-Eleni ManolaGastroenterology Department, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Mantouvalou D. 3, 18454, Athens, Greece.
Gregorios PaspatisGastroenterology Department, General Hospital of Heraklion "Venizeleio - Pananeio", Crete, Greece.
Maria TzouvalaGastroenterology Department, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Mantouvalou D. 3, 18454, Athens, Greece.
General Hospital of Nikea · GRThe General Hospital of Heraklion "Venizeleio-Pananio" · GRKindai University Hospital · JPUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMisdiagnosed sessile serrated lesions (SSLs) are important precursors for interval colorectal cancers.

aimsWe investigated the usage of acetic acid (AA) solution for improving the detection of SSLs in the right colon in a randomized controlled trial.

methodsA tandem observation of the right colon was performed in 412 consecutive patients. A first inspection was performed under white light high-definition endoscopy. In the AA group, a low concentration vinegar solution (AA: 0.005%) irrigated by a water pump in the right colon was compared with a plain solution of normal saline (NS) in the diagnostic yield of SSLs during the second inspection. Secondary outcomes in overall polyp detection were measured.

resultsQualitative comparisons showed significant differences in the detection rates of all polyps except adenomas, with remarkable improvement in the demonstration of advanced (> 20 mm), SSLs, and hyperplastic polyps during the second inspection of the right colon using the AA solution. Significant improvement was also noted in the AA group, as far as the mean number of polyps/patient detected, not only in SSLs (AA group: 0.14 vs. NS group: 0.01, P < 0.001), but also in all histological types and all size-categories in the right colon. Small (≤ 9 mm) polyps were detected at a higher rate in the sigmoid colon expanding the effect of the method in the rest of the colon.

conclusionAA-assisted colonoscopy led to a significant increase in SSLs detection rate in the right colon in a safe, quick, and effective manner.

Indexed as

AdenomaColonic PolypsColorectal NeoplasmsAcetic AcidColon, AscendingColonoscopyDiagnostic ErrorsEarly Detection of CancerFemaleHumansIndicators and ReagentsMaleMiddle AgedPharmaceutical SolutionsQuality ImprovementTherapeutic IrrigationAcetic AcidIndicators and ReagentsPharmaceutical SolutionsAcetic acidChromoendoscopyColonoscopyPolypSessile serrated lesion

Identifiers

PMID33515378
OpenAlexW3124805304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.