Evidence map›Paper›PMID 33515362›Full record

ArticleCancer causes & control : CCC2021

Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer.

O C Martínez-Ramírez, C Castro-Hernández, R Pérez-Morales, L Casas-Ávila, Ramos-García M de Lorena, A Salazar-Piña, J Rubio

Abstract read
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In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

O C Martínez-RamírezFacultad de Nutrición, Universidad Autónoma del Estado de Morelos, Río Iztacihuatl S/N. Col. Vista Hermosa,, C.P. 62350, Ciudad de México, Mexico. celeste.martinez@uaem.mx.ORCID http://orcid.org/0000-0002-1177-5261
C Castro-HernándezDepartamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado, Postal 70228, C.P. 04510, Ciudad de México, Mexico.
R Pérez-MoralesFacultad de Ciencias Químicas, Departamento de Biología Molecular, Universidad Juárez del Estado de Durango, C.P. j35010, Durango, Mexico.
L Casas-ÁvilaDepartamento de Genética, Instituto Nacional de Rehabilitación, C.P. 14389, Ciudad de México, Mexico.
Ramos-García M de LorenaFacultad de Nutrición, Universidad Autónoma del Estado de Morelos, Río Iztacihuatl S/N. Col. Vista Hermosa,, C.P. 62350, Ciudad de México, Mexico.
A Salazar-PiñaFacultad de Nutrición, Universidad Autónoma del Estado de Morelos, Río Iztacihuatl S/N. Col. Vista Hermosa,, C.P. 62350, Ciudad de México, Mexico.
J RubioDepartamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado, Postal 70228, C.P. 04510, Ciudad de México, Mexico.
Universidad Autónoma del Estado de Morelos · MXUniversidad Nacional Autónoma de México · MXInstituto Nacional de Rehabilitación · MXUniversidad Autónoma de la Ciudad de México · MXUniversidad Juárez del Estado de Durango · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged exposure to estrogens is the main factor associated with the risk and prognosis of breast cancer (BC). The genes involved in the biotransformation of estrogens and xenobiotics have allelic variants with modified enzymatic activities. We investigated the association of nine polymorphisms of some genes from the classical estrogen pathway with the risk of breast cancer and their role in the clinicopathological characteristics of poor clinical prognosis in a sample of Mexican women with BC.

methodsWe included 150 controls and 150 cases matched by age. To analyze the selected polymorphisms, TaqMan assays and high-resolution melting (HRM) analysis were used.

resultsThe polymorphisms of the genes ERα, CYP1A1, CYP1B1, COMT, MGMT, and XRCC1 were positively associated with the BC risk. We found negative associations between CYP1B1

conclusionsThe polymorphisms included in this study are associated not only with the risk of BC, but also with some clinicopathological characteristics for poor prognosis of patients with breast cancer, highlighting the important role of CYP1B1 Leu432Val polymorphism.

Indexed as

Breast NeoplasmsAdultCase-Control StudiesEstrogensFemaleGenotypeHumansMexicoPolymorphism, GeneticPrognosisRiskTumor BurdenXenobioticsEstrogensXenobioticsBreast cancerGenetic polymorphismMexican womenPrognosis

Identifiers

PMID33515362
OpenAlexW3122637868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.