Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2021
Risk factors for subsequent vertebral fracture after acute osteoporotic vertebral fractures.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Executive summary: Italian guidelines for diagnosis, risk stratification, and care continuity of fragility fractures 2021.Frontiers in endocrinology · 2023Pooled it
- Predictors of vertebral fractures in patients with severe osteoporosis: a sub-analysis of the Japanese Osteoporosis Intervention Trial-05 (JOINT-05).Archives of osteoporosis · 2025Trial
- Article
- Risk factors for adjacent vertebral fracture after PVP in patients with OVCF.Frontiers in surgery · 2026Article
- Patient education following vertebral fragility fracture: a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Fragility fractures in well-differentiated gastroenteropancreatic neuroendocrine tumors: Results from a multicentered retrospective study.Journal of neuroendocrinology · 2025Article
- Diagnosis of Acute Versus Chronic Thoracolumbar Vertebral Compression Fractures Using CT Radiomics Based on Machine Learning: a Preliminary Study.Journal of imaging informatics in medicine · 2025Article
- Article
- Observational
- Magnetic resonance imaging-based bone and muscle quality parameters for predicting clinical subsequent vertebral fractures after percutaneous vertebral augmentation.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Similarities in distribution pattern between acute multiple osteoporotic vertebral compression fractures and vertebral fractures cascades.Journal of orthopaedic surgery and research · 2024Article
- Prediction of Subsequent Vertebral Fracture After Acute Osteoporotic Fractures from Clinical and Paraspinal Muscle Features.Calcified tissue international · 2024Article
- Article
- Comparative analysis of anti-osteoporosis medications in preventing vertebral body fractures after balloon kyphoplasty.Archives of osteoporosis · 2024Article
- Mortality among older adults with osteoporotic vertebral fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Subsequent Domino Osteoporotic Vertebral Fractures Adversely Affect Short-Term Health-Related Quality of Life: A Prospective Multicenter Study.Medicina (Kaunas, Lithuania) · 2023Article
- Associations between Abdominal Trunk Muscle Weakness and Future Osteoporotic Vertebral Fracture in Middle-Aged and Older Adult Women: A Three-Year Prospective Longitudinal Cohort Study.Journal of clinical medicine · 2022Article
- Association Between Poor Nutritional Status and Increased Risk for Subsequent Vertebral Fracture in Elderly People with Percutaneous Vertebroplasty.Clinical interventions in aging · 2022Article
- Time Course of Acute Vertebral Fractures: A Prospective Multicenter Cohort Study.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
21 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the incidence and characteristics of subsequent vertebral fracture after osteoporotic vertebral fractures (OVFs) and identify risk factors for subsequent vertebral fractures.
methodsThis post-hoc analysis from a prospective randomized multicenter trial included 225 patients with a 48-week follow-up period. Differences between the subsequent and non-subsequent fracture groups were analyzed.
resultsOf the 225 patients, 15 (6.7%) had a subsequent fracture during the 48-week follow-up. The annual incidence of subsequent vertebral fracture after fresh OVFs in women aged 65-85 years was 68.8 per 1000 person-years. Most patients (73.3%) experienced subsequent vertebral fractures within 6 months. At 48 weeks, European Quality of Life-5 Dimensions, the Japanese Orthopedic Association Back Pain Evaluation Questionnaire pain-related disorder, walking ability, social life function, and lumbar function scores were significantly lower, while the visual analog scale (VAS) for low back pain was higher in patients with subsequent fracture. Cox proportional hazards analysis showed that a VAS score ≥ 70 at 0 weeks was an independent predictor of subsequent vertebral fracture. After adjustment for history of previous fracture, there was a ~ 67% reduction in the risk of subsequent vertebral fracture at the rigid-brace treatment.
conclusionWomen with a fresh OVF were at higher risk for subsequent vertebral fracture within the next year. Severe low back pain and use of soft braces were associated with higher risk of subsequent vertebral fractures. Therefore, when treating patients after OVFs with these risk factors, more attention may be needed for the occurrence of subsequent vertebral fractures. LEVEL OF EVIDENCE: III.
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