Evidence map›Paper›PMID 33515271›Full record

ArticleArchives of toxicology2021

Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion.

Onat Kadioglu, Mohamed Saeed, Nuha Mahmoud, Shaymaa Azawi, Kristin Mrasek, Thomas Liehr, Thomas Efferth

Open access · hybridAbstract read
In one paragraph

Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Emerging role of MYB transcription factors in cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Onat KadiogluDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Mohamed SaeedDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Nuha MahmoudDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Shaymaa AzawiInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Kristin MrasekInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Thomas LiehrInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany. efferth@uni-mainz.de.ORCID 0000-0002-2637-1681
Johannes Gutenberg University Mainz · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. In the present study, we characterized colon cancer cells (HCT116 p53

Indexed as

Chromosome AberrationsAntineoplastic AgentsApoptosisColonic NeoplasmsComparative Genomic HybridizationDisease ProgressionDNA Copy Number VariationsDNA RepairDrug Resistance, MultipleDrug Resistance, NeoplasmGene DeletionGene Expression ProfilingGene Expression Regulation, NeoplasticHCT116 CellsHumansIn Situ Hybridization, FluorescenceAntineoplastic AgentsTP53 protein, humanTumor Suppressor Protein p53CancerChromosomal aberrationsDrug resistanceGenomic instabilityLoss-of-functionTranscriptomicsTumor suppressor

Identifiers

PMID33515271
PMCPMC7904745
OpenAlexW3124281795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.