Evidence map›Paper›PMID 33515188›Full record

SynthesisJournal of general internal medicine2021

The Impact of Social Determinants of Health on Medication Adherence: a Systematic Review and Meta-analysis.

Marcee E Wilder, Paige Kulie, Caroline Jensen, Paul Levett, Janice Blanchard, Luis W Dominguez, Maria Portela, Aneil Srivastava, Yixuan Li, Melissa L McCarthy

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06814795 (Feasibility of Medically Tailored Meals for Pediatric Populations at Risk for Disparities in Serious Illness Outcomes Due to Inequities in Social Drivers of Health), which is not on this map. Cited by 143 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06814795 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Feasibility of Medically Tailored Meals for Pediatric Populations at Risk for Disparities in Serious Illness Outcomes Due to Inequities in Social Drivers of Health (MTM-Kids)

TypeinterventionalSponsorUNC Lineberger Comprehensive Cancer CenterRan2025 to 2026Enrolled32ConditionsPediatric CancerArmsMedically tailored meals
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcee E WilderDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA. M.wilder@mfa.gwu.edu.ORCID 0000-0001-6508-4573
Paige KulieDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA.
Caroline JensenAnesthesiology Residency Program, Columbia University, New York, NY, USA.
Paul LevettHimmelfarb Health Sciences Library, George Washington University, Washington, DC, USA.
Janice BlanchardDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA.
Luis W DominguezDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA.
Maria PortelaDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA.
Aneil SrivastavaDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA.
Yixuan LiDepartment of Health Policy and Management, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Melissa L McCarthyDepartment of Emergency Medicine, George Washington University, Medical Faculty Associates, Washington, DC, USA.

Funding

Integrating Social Determinants of Health Into Risk Adjustment Models: An Opportunity to Improve Care Coordination Strategies For Medicaid BeneficiariesR01MD011607 · NIMHD · GEORGE WASHINGTON UNIVERSITY · PI MCCARTHY, MELISSA L · 2017 to 2020
$2.5M
NIMHD NIH HHS R01 MD011607
6 · The paper itself

Abstract

backgroundMedication adherence (MA) is critical to successful chronic disease management. It is not clear how social determinants of health (SDH) impact MA. We conducted a systematic review and meta-analysis to summarize the evidence on the relationship between SDH and MA.

methodsWe conducted a systematic review of the literature using a Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) format. A literature search was performed using three databases: PubMed, Scopus, and Cochrane Clinical Trials Register in December of 2018. Included studies were completed in the USA, included adults aged 18 years and older, measured at least one social determinant of health, and medication adherence was the primary outcome measure. Data from included full texts were independently extracted using a standardized data extraction form. We then conducted a meta-analysis and pooled the odds ratios from the included studies for each social determinant as well as for all SDH factors collectively.

resultsA total of 3137 unduplicated abstracts were identified from our database searches. A total of 173 were selected for full text review after evaluating the abstract. A total of 29 articles were included for this systematic review. Economic-related SDH factors and MA were mostly commonly examined. The meta-analysis revealed a significant relationship between food insecurity (aOR = 0.56; 95% CI 0.42-0.7), housing instability (aOR = 0.64; 95% CI 0.44-0.93), and social determinants overall (aOR = 0.75; 95% CI 0.65-0.88) and medication adherence. DISCUSSION: Food insecurity and housing instability most consistently impacted medication adherence. Although included studies were heterogenous and varied widely in SDH and MA measurements, adverse social determinants overall were significantly associated with lower MA. The relationship between SDH and MA warrants more attention and research by health care providers and policymakers.

Indexed as

Medication AdherenceSocial Determinants of HealthAdultHousingHumansmedication adherencesocial determinants of health

Identifiers

PMID33515188
PMCPMC8131473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.