ArticleMetabolomics : Official journal of the Metabolomic Society2021
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies.
Article in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Observational
- Metabolomic profiling reveals key metabolic pathway alterations in monochorionic diamniotic twins with selective intrauterine growth restriction.BMC pregnancy and childbirth · 2026Article
- Subtype specific immune-metabolic reprogramming in preeclampsia revealed by multiomics and serum biomarkers.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Metabolomic insights: LC-MS profiling of human placental tissue from SSRI-treated pregnancies.European journal of medical research · 2026Article
- Metabonomics of serum bile acids in patients with pre-eclampsia.Scientific reports · 2025Article
- Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Sexually dimorphic impact of prenatal hyperandrogenism on offspring growth trajectory in sheep.Scientific reports · 2025Article
- Metabolic profiles of meconium in preeclamptic and normotensive pregnancies.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems.Environmental health perspectives · 2025Article
- The role of puff volume in vaping emissions, inhalation risks, and metabolic perturbations: a pilot study.Scientific reports · 2024Article
- Gestational testosterone excess early to mid-pregnancy disrupts maternal lipid homeostasis and activates biosynthesis of phosphoinositides and phosphatidylethanolamines in sheep.Scientific reports · 2024Article
- Gut metabolic changes during pregnancy reveal the importance of gastrointestinal region in sample collection.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Article
- 5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes.Nutrition & diabetes · 2023Article
- Association of serum metabolome profile with the risk of breast cancer in participants of the HUNT2 study.Frontiers in oncology · 2023Article
- Inconsistent nomenclature of microbiota-associated metabolites hampers progress of the field.Nature metabolism · 2022Article
- Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta.BMC microbiology · 2022Article
- Identification of Biomarkers for Preeclampsia Based on Metabolomics.Clinical epidemiology · 2022Review
- The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review.International journal of tryptophan research : IJTR · 2022Review
- Bridging the Polar and Hydrophobic Metabolome in Single-Run Untargeted Liquid Chromatography-Mass Spectrometry Dried Blood Spot Metabolomics for Clinical Purposes.Journal of proteome research · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
introductionMaternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation. OBJECTIVES AND
methodsWe applied liquid chromatography-mass spectrometry (LC-MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy.
resultsProgression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The metabolic signatures of pregnancy were largely shared in pre-eclamptic and healthy women, only urea, monoacylglyceride 18:1 and glycerophosphocholine were identified to be increased in the pre-eclamptic women when compared to healthy controls.
conclusionsOur study highlights the need of large-scale longitudinal metabolomic studies in non-complicated pregnancies before more detailed understanding of metabolism in adverse outcomes could be provided. Our findings are one of the first steps for a broader metabolic understanding of the physiological changes caused by pregnancy per se.
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