ArticleJournal of neurology2021
Sneddon syndrome: a comprehensive clinical review of 53 patients.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Long-term clinical progression of Sneddon syndrome associated with antiphospholipid syndrome.Dementia & neuropsychologia · 2026Article
- Central retinal artery occlusion as the initial manifestation of mixed connective tissue disease in a young woman: a case report.BMC ophthalmology · 2024Article
- Dermatologic manifestations of hematologic disorders.Annals of hematology · 2024Review
- An unusual case of intracerebral hemorrhage: exploring the link with Sneddon's syndrome.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Comprehensive insights of Sneddon syndrome: A clinical perspective.Journal of central nervous system disease · 2024Review
- Sneddon's syndrome concurrent with cerebral venous sinus thrombosis: A case report.World journal of clinical cases · 2023Article
- Article
- Neuropsychiatric Manifestations of Antiphospholipid Syndrome-A Narrative Review.Brain sciences · 2022Review
- The diagnostic value of skin biopsies in Sneddon syndrome.PloS one · 2021Article
- Sneddon's Syndrome and the Capability to Work: With Regard to a Clinical Case.Indian journal of occupational and environmental medicineArticle
- Inadequate response to antiplatelet therapy in Sneddon's syndrome. Time to re-evaluate management recommendations?Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of livedo reticularis in patients with ischaemic stroke is associated with Sneddon syndrome (SS). Our objective was to present the clinical features of SS patients and to assess the role of antiphospholipid antibodies (APL).
methodsConsecutive patients, diagnosed with SS between 1996 and 2017, were retrospectively reviewed for their demographic, neurological, dermatological, cardiac and extracerebral vascular features. Diagnosis of SS was made only if other causes of stroke were excluded. Patients with and without APL were included and compared for their clinical features.
resultsFifty-three patients (79% female) were included, of whom 14 patients were APL-positive. Median age at diagnosis was 40 years. Approximately 60% of the patients had ≥ 3 cardiovascular risk factors. There were 129 previous vascular events (66 ischaemic strokes, 62 TIAs and 1 amaurosis fugax) during a median period of 2 years between the first event and diagnosis of SS. Skin biopsy was positive for SS in 29 patients (67%), mostly showing a thickened vessel wall with neovascularization in the deep dermis. After a median follow-up of 28 months, 4 patients, either on antiplatelet or oral anticoagulation therapy, had a recurrent stroke. There were few statistically significant differences between APL-negative and APL-positive patients, including the number of vascular events before diagnosis.
conclusionsSS predominantly affects young women with a relatively large number of cardiovascular risk factors. Clinical features of SS are comparable across different studies. We found no differences in the main clinical features between APL-positive and APL-negative patients.
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