ArticleSocial cognitive and affective neuroscience2021
In Search of the Most Reproducible Neural Vulnerability Factors that Predict Future Weight Gain: Analyses of Data from Six Prospective Studies.
Article in Social cognitive and affective neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Elevated reward, emotion, and memory region response to thin models predicts eating disorder symptom persistence: A prospective functional magnetic resonance imaging study.Journal of psychopathology and clinical science · 2023Trial
- Efficacy of a food response and attention training treatment for obesity: A randomized placebo controlled trial.Behaviour research and therapy · 2022Trial
- Neurocognitive factors predicting BMI changes from adolescence to young adulthood.Obesity (Silver Spring, Md.) · 2024Article
- The social neuroscience of eating: an introduction to the special issue.Social cognitive and affective neuroscience · 2023Article
- Efficacy of a combined food-response inhibition and attention training for weight loss.Current opinion in behavioral sciences · 2022Article
- Brain Responses to Food Choices and Decisions Depend on Individual Hedonic Profiles and Eating Habits in Healthy Young Women.Frontiers in nutrition · 2022Article
- Neural Vulnerability Factors That Predict Future Weight Gain.Current obesity reports · 2021Review
- Test-retest reliability of functional MRI food receipt, anticipated receipt, and picture tasks.The American journal of clinical nutrition · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We tested if we could replicate the main effect relations of elevated striatum and lateral orbitofrontal cortex (OFC) response to high-calorie food stimuli to weight gain reported in past papers in six prospective datasets that used similar fMRI paradigms. Participants in Study 1 (N = 37; M age = 15.5), Study 2 (N = 160; M age = 15.3), Study 3 (N = 130; M age = 15.0), Study 4 (N = 175; M age = 14.3), Study 5 (N = 45; M age = 20.8), and Study 6 (N = 49; M age = 31.1) completed fMRI scans at baseline and had their BMI and body fat (Studies 4 and 6 only) measured at baseline and over follow-ups. Elevated striatal response to palatable food images predicted BMI gain in Studies 1 and 6 and body fat gain in Study 6. Lateral OFC activation did not predict weight gain in any of the six studies. Results provide limited support for the hypothesis that elevated reward region responsivity to palatable food images predicts weight gain. Factors that make replication difficult are discussed and potential solutions considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.