ArticleNature chemistry2021
Mechanochemical bond scission for the activation of drugs.
Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed.
- Stress Transfer Within Microphase-Separated Structures: A Post-Synthetic Strategy to Impart Mechanoresponsiveness to Block Copolymer Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Subcellular photochemistry for precision spatial protein targeting.Nature reviews. Chemistry · 2026Review
- Forces in mechanically interlocked materials.Chemical Society reviews · 2026Review
- Tailored Nanogel Network Topology Enables Clinical Ultrasound-Induced Mechanochemical Activation for In Vivo Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Mechanically Regulated Nanozymes for Remote Metabolic Reprogramming and Precise Cancer Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Mechanochemical disassembly pathways of self-assembled polymer-decorated PdNature communications · 2026Article
- Advances in Camptothecin-Class Compounds Nanomedicines: A Comprehensive Review of Antitumor Strategies.Pharmaceutics · 2026Review
- The mechanochemical activation of a pyrimidine dimer.Chemical science · 2026Article
- Focused ultrasound for cellular mechanoactivation and nanomedicine delivery in cancer.Biomedical microdevices · 2026Review
- Ultrasound-Activated Prodrugs for Precision Cancer Therapy: From Mechanical and Cavitation Effects to Advanced Sonochemical Activation.Chem & bio engineering · 2026Review
- Size-Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano-Nanoswitches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modulating a Massive Set of Biomolecular Structures by Sono-Mechanical Force.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in ultrasound-assisted drug delivery and clinical application.Ultrasonics sonochemistry · 2026Review
- Recent advances in tumor-activated prodrug nanoparticles for cancer immunotherapy.Frontiers in immunology · 2026Review
- Recoverable Fluorination Accelerates Ring-Opening Copolymerisation and Enables Post-Polymerisation-Modification of Polyesters.Angewandte Chemie (International ed. in English) · 2025Article
- ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound.Drug delivery · 2025Article
- Synthetic mechanoreceptor engineering: From genetic encoding to DNA nanotechnology-based reprogramming.Mechanobiology in medicine · 2025Review
- Preparation of mechano-nanoswitches for ultrasound-controlled drug activation.Biophysics reports · 2025Article
- Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration.RSC advances · 2025Article
- Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator.Angewandte Chemie (International ed. in English) · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmaceutical drug therapy is often hindered by issues caused by poor drug selectivity, including unwanted side effects and drug resistance. Spatial and temporal control over drug activation in response to stimuli is a promising strategy to attenuate and circumvent these problems. Here we use ultrasound to activate drugs from inactive macromolecules or nano-assemblies through the controlled scission of mechanochemically labile covalent bonds and weak non-covalent bonds. We show that a polymer with a disulfide motif at the centre of the main chain releases an alkaloid-based anticancer drug from its β-carbonate linker by a force-induced intramolecular 5-exo-trig cyclization. Second, aminoglycoside antibiotics complexed by a multi-aptamer RNA structure are activated by the mechanochemical opening and scission of the nucleic acid backbone. Lastly, nanoparticle-polymer and nanoparticle-nanoparticle assemblies held together by hydrogen bonds between the peptide antibiotic vancomycin and its complementary peptide target are activated by force-induced scission of hydrogen bonds. This work demonstrates the potential of ultrasound to activate mechanoresponsive prodrug systems.
Indexed as
Identifiers
33514936What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.