Evidence map›Paper›PMID 33514869›Full record

Trial reportEuropean journal of clinical nutrition2021

Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.

Xuelong Li, Ying Liu, Xiaofei Guo, Yan Ma, Huaqi Zhang, Hui Liang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Improving Lipid Profiles ThroughFoods (Basel, Switzerland) · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
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  16. Review
  17. Review
  18. Nutrients · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuelong LiDepartment of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China.ORCID http://orcid.org/0000-0003-3967-3168
Ying LiuBasic Medical College, Qingdao University of Medicine, 308 Ningxia Road, Qingdao, 266071, China.
Xiaofei GuoDepartment of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China.
Yan MaDepartment of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China.
Huaqi ZhangDepartment of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China.
Hui LiangDepartment of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China. qdlianghui@qdu.edu.cn.ORCID http://orcid.org/0000-0003-4702-8468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study aims to investigate the effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.

methodsIn a double-blind randomized controlled trial, 158 recruited alcoholic liver injury patients were randomized to three treatments for 60 days: low-dose group (LP, n = 58, 100 ml of Lactobacillus casei strain Shirota (LcS)), high-dose group (HP, n = 54, 200 ml of LcS), and positive control group (PC, n = 46, 100 ml of special drinks without active Lactobacillus casei). Another group of 20 healthy people was served as normal control group (NC).

resultsThe serum levels of TG and LDLC in the HP group were significantly decreased by 26.56% and 23.83%, respectively than those in the PC group (P < 0.05). After supplementation of Lactobacillus casei, there was a significant increase in the amount of Lactobacillus and Bifidobacterium when compared with the PC group (P < 0.05).

conclusionsSupplementation of Lactobacillus casei can improve lipid metabolism and regulate intestinal flora disorders in patients with alcoholic liver injury.

Indexed as

Gastrointestinal MicrobiomeLacticaseibacillus caseiLipid MetabolismLiver Diseases, AlcoholicProbioticsHumansLiver

Identifiers

PMID33514869
PMCPMC8352779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.