Evidence map›Paper›PMID 33514864›Full record

ArticleCommunications biology2021

Hallmarks of primary neurulation are conserved in the zebrafish forebrain.

Jonathan M Werner, Maraki Y Negesse, Dominique L Brooks, Allyson R Caldwell, Jafira M Johnson, Rachel M Brewster

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Ubiquitin ligases: guardians of mammalian development.Nature reviews. Molecular cell biology · 2022
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jonathan M Werner *Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA.
Maraki Y Negesse *Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA.ORCID 0000-0002-2818-285X
Dominique L BrooksDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA.
Allyson R CaldwellDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA.
Jafira M JohnsonDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA.
Rachel M BrewsterDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA. brewster@umbc.edu.ORCID 0000-0002-9058-2045
University of Maryland, Baltimore County · US

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
U-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5M
Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R25 GM055036NIGMS NIH HHS T32 GM066706NIGMS NIH HHS T34 GM136497
6 · The paper itself

Abstract

Primary neurulation is the process by which the neural tube, the central nervous system precursor, is formed from the neural plate. Incomplete neural tube closure occurs frequently, yet underlying causes remain poorly understood. Developmental studies in amniotes and amphibians have identified hingepoint and neural fold formation as key morphogenetic events and hallmarks of primary neurulation, the disruption of which causes neural tube defects. In contrast, the mode of neurulation in teleosts has remained highly debated. Teleosts are thought to have evolved a unique mode of neurulation, whereby the neural plate infolds in absence of hingepoints and neural folds, at least in the hindbrain/trunk where it has been studied. Using high-resolution imaging and time-lapse microscopy, we show here the presence of these morphological landmarks in the zebrafish anterior neural plate. These results reveal similarities between neurulation in teleosts and other vertebrates and hence the suitability of zebrafish to understand human neurulation.

Indexed as

NeurulationAnimalsAnimals, Genetically ModifiedCell MovementCell ShapeEmpty Spiracles Homeobox ProteinsEpithelial CellsHomeodomain ProteinsLuminescent ProteinsMorphogenesisNeural PlateNeural TubeNeural Tube DefectsProsencephalonRecombinant Fusion ProteinsTime FactorsEmpty Spiracles Homeobox ProteinsHomeodomain ProteinsLuminescent ProteinsRecombinant Fusion ProteinsTranscription Factors

Identifiers

PMID33514864
PMCPMC7846805
OpenAlexW3123978917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.