ArticleNature communications2021
Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 165 citations in OpenAlex.
- Pathogen-Induced Cell Wall Remodeling and Immune Signaling in Plants.The plant pathology journal · 2026Review
- The Plant Cell Wall: From Structural Diversity and Biosynthesis to Integrity Signaling and Physiological Functions.Plants (Basel, Switzerland) · 2026Review
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor.The New phytologist · 2026Article
- A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3.Nature plants · 2026Article
- Small Peptides, Smart Plants: The Emerging Significance of SCOOP Signalling.Plant, cell & environment · 2026Review
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots.Developmental cell · 2026Article
- Diverse phytocytokines derived from conserved subtilase scaffolds co-evolved with clustered receptors to confer defence responses in legumes.Nature plants · 2026Article
- Plant Peptide Hormones: Distinctive Horizons in Plant Development and Stress Resilience.Plant, cell & environment · 2026Review
- Epigenetic regulation of TaFIP phytocytokine clusters confers basal resistance via receptor kinase TaFIPR in wheat.Nature plants · 2026Article
- Advances in the roles of SCOOP peptides and the receptor-like kinase MIK2 in plant stress responses.Plant cell reports · 2026Review
- Plant Peptides on the Rise: From Historical Insight to Future Applications.Plant biotechnology journal · 2026Review
- Processing and release of endogenous immunogenic peptide signals.The Plant journal : for cell and molecular biology · 2026Review
- Plant cell wall remodeling and peptide signaling under abiotic and biotic stress.Plant communications · 2026Review
- Plant subtilases as key initiators of peptide ligand-receptor signaling.The Plant journal : for cell and molecular biology · 2026Review
- Unraveling plant immunity: from pathogen perception to resistance engineering.Science China. Life sciences · 2026Review
- The transformative power of structural predictions with AI in plant science.The Plant journal : for cell and molecular biology · 2026Review
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant genomes encode hundreds of receptor kinases and peptides, but the number of known plant receptor-ligand pairs is limited. We report that the Arabidopsis leucine-rich repeat receptor kinase LRR-RK MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2) is the receptor for the SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) phytocytokines. MIK2 is necessary and sufficient for immune responses triggered by multiple SCOOP peptides, suggesting that MIK2 is the receptor for this divergent family of peptides. Accordingly, the SCOOP12 peptide directly binds MIK2 and triggers complex formation between MIK2 and the BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) co-receptor. MIK2 is required for resistance to the important root pathogen Fusarium oxysporum. Notably, we reveal that Fusarium proteomes encode SCOOP-like sequences, and corresponding synthetic peptides induce MIK2-dependent immune responses. These results suggest that MIK2 may recognise Fusarium-derived SCOOP-like sequences to induce immunity against Fusarium. The definition of SCOOPs as MIK2 ligands will help to unravel the multiple roles played by MIK2 during plant growth, development and stress responses.
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