ArticleNature communications2021
PDX1
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 80 citations in OpenAlex.
- The comparative cell physiology of stem cell-derived and primary human β cells.Nature reviews. Endocrinology · 2026Review
- A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes.bioRxiv : the preprint server for biology · 2026Article
- eNAMPT induces alpha-cell mass expansion but impaired glucagon counter regulatory response.Endocrinology · 2026Article
- Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective.Cells · 2026Review
- CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress.Diabetes · 2025Article
- Spatially bound functional heterogeneity drives modular organization in β-cell networks.Biophysical journal · 2025Article
- Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells.Nature reviews. Endocrinology · 2025Review
- Scaffold-free endocrine tissue engineering: role of islet organization and implications in type 1 diabetes.BMC endocrine disorders · 2025Review
- Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet CaeLife · 2025Article
- Biphasic glucose-stimulated insulin secretion over decades: a journey from measurements and modeling to mechanistic insights.Life metabolism · 2025Review
- Cumulative atherosclerosis index of plasma exposure and new-onset diabetes in middle-aged and older adults: a prospective cohort analysis from the China Health and Retirement Longitudinal Study.Frontiers in nutrition · 2025Article
- Huanglian-Renshen-Decoction Maintains Islet β-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine.Chinese journal of integrative medicine · 2025Article
- Glucokinase activity controls peripherally-located subpopulations of β-cells that lead islet CabioRxiv : the preprint server for biology · 2024Article
- Exploring pancreatic beta-cell subgroups and their connectivity.Nature metabolism · 2024Review
- Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity.Diabetologia · 2024Article
- LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.Cell reports · 2024Article
- Synchronizing beta cells in the pancreas.eLife · 2024Article
- Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators.Frontiers in cell and developmental biology · 2024Review
- Differential CpG methylation atbioRxiv : the preprint server for biology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 7 institutions in 5 countries.
Daniela NasteskaInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Nicholas H F FineInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-2343-8534
Fiona B AshfordInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Federica CuozzoInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-8399-1281
Katrina ViloriaInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Gabrielle SmithInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Aisha DahirInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Peter W J DawsonSchool of Sport, Exercise and Rehabilitation Science, University of Birmingham, Edgbaston, UK.
Yu-Chiang LaiInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Aimée Bastidas-PonceInstitute of Diabetes and Regeneration Research, Helmholtz Zentrum München, D-85764, Neuherberg, Germany.
Mostafa BakhtiInstitute of Diabetes and Regeneration Research, Helmholtz Zentrum München, D-85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-2307-1122
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Reproduction, and Digestion, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6360-0343
Remi FiancetteInstitute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Rita NanoSan Raffaele Diabetes Research Institute, IRCCS Ospedale, San Raffaele, Italy.
Lorenzo PiemontiSan Raffaele Diabetes Research Institute, IRCCS Ospedale, San Raffaele, Italy.ORCID http://orcid.org/0000-0002-2172-2198
Heiko LickertInstitute of Diabetes and Regeneration Research, Helmholtz Zentrum München, D-85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4597-8825
Qiao ZhouDivision of Regenerative Medicine, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Ildem AkermanInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-9875-1421
David J HodsonInstitute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK. d.hodson@bham.ac.uk.ORCID http://orcid.org/0000-0002-8641-8568
University of Nottingham · GBUniversity of Birmingham · GBHelmholtz Zentrum München · DEArthritis UK · GBVita-Salute San Raffaele University · ITCornell University · USNanyang Technological University · SG
Funding
Reprogram gastric tissue to functional insulin-secreting cellsR01DK106253 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, QIAO JOE · 2016 to 2020
$2.5MGenerating novel sources of functional human insulin-secreting cells for T1D modelingUC4DK116280 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, QIAO JOE · 2017 to 2017
$2.1MMedical Research Council MR/J0003042/1Medical Research Council MR/L020149/1Medical Research Council MR/L02036X/1Medical Research Council MR/N00275X/1Medical Research Council MR/R022259/1Medical Research Council MR/S025618/1NIDDK NIH HHS R01 DK106253NIDDK NIH HHS UC4 DK116280Wellcome TrustWellcome Trust 212625/Z/18/ZWellcome Trust WT098424AIA
Abstract
Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA expression, contribute to islet operation. Functional mapping of rodent and human islets containing proportionally more PDX1
Indexed as
AnimalsCalciumCells, CulturedDiabetes Mellitus, Type 2FemaleGene Knock-In TechniquesHomeodomain ProteinsHumansInsulin-Secreting CellsInsulin SecretionMaf Transcription Factors, LargeMaleMiceMice, TransgenicModels, AnimalPrimary Cell CultureCalciumHomeodomain ProteinsMAFA protein, humanMafa protein, mouseMaf Transcription Factors, Largepancreatic and duodenal homeobox 1 proteinTrans-Activators
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.