Evidence map›Paper›PMID 33514659›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

A glycan FRET assay for detection and characterization of catalytic antibodies to the

Conor J Crawford, Maggie P Wear, Daniel F Q Smith, Clotilde d'Errico, Scott A McConnell, Arturo Casadevall, Stefan Oscarson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Activity-Based Tracking of Glycan Turnover in Microbiomes.Journal of the American Chemical Society · 2025
    Article
  3. Article
  4. Article
  5. Catalytic Protein Inhibitors.Angewandte Chemie (International ed. in English) · 2024
    Review
  6. Serum antibody screening using glycan arrays.Chemical Society reviews · 2024
    Review
  7. The structure of aProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Semi-synthetic glycoconjugate vaccine candidate againstbioRxiv : the preprint server for biology · 2024
    Article
  10. Methods of Cryptococcal Polysaccharide Analysis Using ELISA.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  11. The structure of abioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Conor J CrawfordCentre for Synthesis and Chemical Biology, University College Dublin, Dublin 4, Ireland.ORCID 0000-0002-1314-1019
Maggie P WearDepartment of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Daniel F Q SmithDepartment of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.ORCID 0000-0002-7674-9988
Clotilde d'ErricoCentre for Synthesis and Chemical Biology, University College Dublin, Dublin 4, Ireland.ORCID 0000-0001-8996-4057
Scott A McConnellDepartment of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 acasade1@jhu.edu stefan.oscarson@ucd.ie.ORCID 0000-0002-9402-9167
Stefan OscarsonCentre for Synthesis and Chemical Biology, University College Dublin, Dublin 4, Ireland; acasade1@jhu.edu stefan.oscarson@ucd.ie.ORCID 0000-0002-8273-4918
Johns Hopkins University · USUniversity College Dublin · IE

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
Malaria and Mosquito/Tick-borne DiseasesT32AI138953 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DAVID Joseph SULLIVAN · 2019 to 2026
$2.0M
NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI152078NIAID NIH HHS T32 AI007417NIAID NIH HHS T32 AI138953
6 · The paper itself

Abstract

Classic antibody functions include opsonization, complement activation, and enhancement of cellular antimicrobial function. Antibodies can also have catalytic activity, although the contribution of catalysis to their biological functions has been more difficult to establish. With the ubiquity of catalytic antibodies against glycans virtually unknown, we sought to advance this knowledge. The use of a glycan microarray allowed epitope mapping of several monoclonal antibodies (mAbs) against the capsule of

Indexed as

Biological AssayFluorescence Resonance Energy TransferAntibodies, CatalyticAntibodies, FungalComplement System ProteinsCryptococcus neoformansEpitope MappingKineticsMacrophagesModels, MolecularMolecular ProbesOligosaccharidesPeptidesPhagocytosisPolysaccharidesProtein Structure, SecondaryAntibodies, CatalyticAntibodies, FungalComplement System ProteinsMolecular ProbesOligosaccharidesPeptidesPolysaccharideschemical biologyfungiglucuronoxylomannanglycanshost–microbe interactions

Identifiers

PMID33514659
PMCPMC7865134
OpenAlexW3123312618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.