ArticleNeurology2021
Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [
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In one paragraph
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Neuroinflammatory markers sTREM2 and YKL-40 in association with Alzheimer's disease pathology: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Diabetes-Associated Cognitive Impairment: Pathophysiology and Emerging Therapies.Annals of clinical and translational neurology · 2026Review
- Dual association patterns between microglial activation and neuronal health in Alzheimer's disease: a whole-brain MRSI/PET study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Non-invasive identification of brain signatures of acute liver injury.Theranostics · 2026Article
- Imaging brain inflammation and blood brain barrier permeability in neurological and psychiatric diseases: a review.Journal of neuroinflammation · 2025Review
- Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer's disease.Acta neuropathologica · 2025Article
- Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses.NPJ Parkinson's disease · 2024Article
- Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury.bioRxiv : the preprint server for biology · 2024Article
- Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau.Annals of neurology · 2024Article
- Associations between sex, body mass index and the individual microglial response in Alzheimer's disease.Journal of neuroinflammation · 2024Article
- Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.Molecular psychiatry · 2023Article
- Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.Alzheimer's research & therapy · 2023Article
- The Vascular-Immune Hypothesis of Alzheimer's Disease.Biomedicines · 2023Review
- Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease.Research (Washington, D.C.) · 2023Article
- Brain PET Imaging: Approach to Cognitive Impairment and Dementia.PET clinics · 2023Review
- Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer's disease.Frontiers in neurology · 2023Article
- Cognitive Dysfunction in Patients Treated with Androgen Deprivation Therapy: A Multimodality Functional Imaging Study to Evaluate Neuroinflammation.Prostate cancer · 2023Article
- A dual tracer [Bioelectronic medicine · 2022Article
- Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up.Neurology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Sini ToppalaFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland. sini.toppala@utu.fi.ORCID 0000-0002-4506-9584
Laura L EkbladFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.ORCID 0000-0002-5863-8088
Jouni TuiskuFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.ORCID 0000-0003-0965-9365
Semi HelinFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Jarkko J JohanssonFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Hanna LaineFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Eliisa LöyttyniemiFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Päivi MarjamäkiFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Kaj BlennowFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Henrik ZetterbergFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Antti JulaFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Matti ViitanenFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
Juha O RinneFrom the Turku PET Centre (S.T., L.L.E., J.T., S.H., J.J., P.M., J.O.R.) and Department of Biostatistics (E.L.), University of Turku; Kuopio City Home Care (S.T.), Rehabilitation and Medical Services for Elderly, Kuopio, Finland; Amsterdam Alzheimer Center (L.L.E.), Amsterdam UMC, the Netherlands; Department of Radiation Sciences (J.J.), Umeå University, Sweden; City of Turku (H.L.), Welfare Division, Turku City Hospital, Turku, Finland; Department of Medicine (H.L.), University of Turku, Turku University Hospital, Finland; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; National Institute for Health and Welfare (A.J.); Department of Geriatrics (M.V.), Turku City Hospital; University of Turku (M.V.), Finland; Division of Clinical Geriatrics (M.V.), NVS, Karolinska Institutet, Stockholm, Sweden; and Division of Clinical Neurosciences (J.O.R.), Turku University Hospital, Finland.
University of Turku · FI
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether early β-amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia.
methodsWe examined 54 volunteers (mean age 70.0 years, 56% women, 51%
resultsAmong the whole study group, no significant association was found between [
conclusionsWhile there was no association between amyloid and neuroinflammation in the overall study group, neuroinflammation was associated with amyloid among the subgroup at early stages of amyloid pathology.
Indexed as
AgedAged, 80 and overAmyloid beta-PeptidesAniline CompoundsBrainFemaleFinlandHumansInflammationMagnetic Resonance ImagingMaleNeuroimagingPositron-Emission TomographyPyrimidinesRadiopharmaceuticalsReceptors, GABA2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline Compounds(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinaminePyrimidinesRadiopharmaceuticalsReceptors, GABAThiazolesTSPO protein, human
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