ReviewArchives of disease in childhood. Fetal and neonatal edition2021
Parenteral lipid emulsions in the preterm infant: current issues and controversies.
Review in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Essential fatty acid deficiency, olive oil-based intravenous lipid emulsion, and genetic polymorphisms: A pediatric randomized controlled trial.Journal of pediatric gastroenterology and nutrition · 2025Trial
- Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid: A secondary analysis of the Mega Donna Mega trial.Clinical nutrition (Edinburgh, Scotland) · 2023Trial
- Comparison of growth and morbidity outcomes in preterm infants using two different intravenous lipid emulsions.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association between multi-oil fat emulsion and bronchopulmonary dysplasia in preterm infants <32 weeks.Translational pediatrics · 2026Article
- Bridging the Gap in the Clinical Application of Advanced Parenteral Nutrition Formulations: From Efficacy to Real-World Challenges.Advances in nutrition (Bethesda, Md.) · 2026Review
- Lipidomics Reveals Circulating Lipid Biomarkers for Retinopathy of Prematurity in Preterm Infants.Ophthalmology science · 2026Article
- Lipid emulsion modulates myogenic and collagen-related gene expression in skeletal muscle of preterm fetal sheep.Experimental physiology · 2026Article
- First, do no trend: aligning parenteral lipid therapy with physiology and evidence in neonates.Pediatric research · 2026Article
- Early-onset preeclampsia exposure and hospital outcomes of very preterm infants: a retrospective analysis of feeding intolerance and hospital morbidities.Frontiers in pediatrics · 2026Article
- Fatty acid profiles in blood and tissues of parenteral nutrition-fed neonatal piglets using a novel lipid emulsion containing choline.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Measures of nutrition intake and growth reported in preterm nutrition studies: A scoping review.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Clinical Management of Dyslipidemia in Infants and Toddlers.Current atherosclerosis reports · 2025Review
- Postnatal growth restriction impairs rat lung structure and function.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Essential fatty acid deficiency in parenteral nutrition: Historical perspective and modern solutions, a narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Review
- From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide.Pediatric transplantation · 2024Review
- Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates.Life (Basel, Switzerland) · 2023Review
- Lipids and Long Chain Polyunsaturated Fatty Acids in Preterm Infants.Clinics in perinatology · 2022Review
- Current Strategies to Optimize Nutrition and Growth in Newborns and Infants with Congenital Heart Disease: A Narrative Review.Journal of clinical medicine · 2022Review
- Association of fish oil containing lipid emulsions with retinopathy of prematurity: a retrospective observational study.BMC pediatrics · 2022Observational
- A Mixed-Lipid Emulsion Containing Fish Oil for the Parenteral Nutrition of Preterm Infants: No Impact on Visual Neuronal Conduction.Nutrients · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Parenteral lipid emulsions are a necessary component of nutrition for extremely low gestational age newborns until adequate levels of enteral intake are established. Historically, Intralipid, a 100% soybean oil emulsion, has filled this role. Newer multicomponent lipid emulsions containing a mixture of other oils, including olive oil and fish oil, are now available as options, although the regulatory approval for use in neonates varies worldwide. When dosed at currently published recommendations, each of these lipid emulsions meets total fat and energy requirements without a risk of essential fatty acid deficiency. Thus, when choosing which lipid emulsion to provide, the answer must be based on the metabolic differences induced as a result of these fatty acid-rich emulsions and whether the emulsions provide a health advantage or pose a health risk. The questions of induced fatty acid profiles, health benefit and health risk are discussed sequentially for multicomponent lipid emulsions. Despite the growing acceptance of multicomponent lipid emulsions, there is concern regarding changes in blood fatty acid levels and potential health risk without strong evidence of benefit. There remains no ideal parenteral lipid emulsion option for the preterm infant. Standardising future animal and human studies in lipid delivery with the inclusion of lipid metabolism data will iteratively provide answers to inform the optimal lipid emulsion for the preterm infant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.