Evidence map›Paper›PMID 33514624›Full record

ArticleGenome research2021

Orc4 spatiotemporally stabilizes centromeric chromatin.

Lakshmi Sreekumar, Kiran Kumari, Krishnendu Guin, Asif Bakshi, Neha Varshney, Bhagya C Thimmappa, Leelavati Narlikar, Ranjith Padinhateeri, Rahul Siddharthan, Kaustuv Sanyal

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Organization principles of dynamic three-dimensional genome architecture associated with centromere clustering states.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Lakshmi SreekumarMolecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.ORCID 0000-0002-1849-4374
Kiran KumariDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Krishnendu GuinMolecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.ORCID 0000-0001-6957-465X
Asif BakshiMolecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.ORCID 0000-0002-3987-304X
Neha VarshneyMolecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.ORCID 0000-0002-2780-3028
Bhagya C ThimmappaMolecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
Leelavati NarlikarDepartment of Chemical Engineering, CSIR-National Chemical Laboratory, Pune 411008, India.ORCID 0000-0001-6820-1878
Ranjith PadinhateeriDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.ORCID 0000-0001-5485-1474
Rahul SiddharthanThe Institute of Mathematical Sciences/HBNI, Taramani, Chennai 600113, India.ORCID 0000-0002-2233-0954
Kaustuv SanyalMolecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.ORCID 0000-0002-6611-4073
Jawaharlal Nehru Centre for Advanced Scientific Research · INIndian Institute of Technology Bombay · INInstitute of Mathematical Sciences · INNational Chemical Laboratory · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The establishment of centromeric chromatin and its propagation by the centromere-specific histone CENPA is mediated by epigenetic mechanisms in most eukaryotes. DNA replication origins, origin binding proteins, and replication timing of centromere DNA are important determinants of centromere function. The epigenetically regulated regional centromeres in the budding yeast

Indexed as

Candida albicansCentromereChromatinHistonesKinetochoresOrigin Recognition ComplexReplication OriginChromatinHistonesOrigin Recognition Complex

Identifiers

PMID33514624
PMCPMC8015856
OpenAlexW3122513099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.