Evidence map›Paper›PMID 33514602›Full record

ArticleeNeuro

Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells.

Alejandro Parga Becerra, Aric F Logsdon, William A Banks, Christopher B Ransom

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Suppression of In Vitro Epileptiform Activity by GABA Transaminase Inhibition Is Dependent on GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Mitochondrial Glutamine Metabolism Drives Epileptogenesis in Primary Hippocampal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. The effect of traumatic brain injury on learning and memory: A synaptic focus.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Virally-induced expression of GABAProgress in neurobiology · 2022
    Article
  14. Selective Inhibitory Circuit Dysfunction after Chronic Frontal Lobe Contusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  15. Article
  16. Zolpidem Profoundly Augments Spared Tonic GABAFrontiers in systems neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alejandro Parga BecerraEpilepsy Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98108.
Aric F LogsdonGeriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108.
William A BanksGeriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108.
Christopher B RansomEpilepsy Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98108 cbr5@uw.edu.
University of Washington · USVA Puget Sound Health Care System · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Regulation of extraysynaptic GABA-A receptors in health and diseaseI01BX002745 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI RANSOM, CHRISTOPHER BRUCE · 2016 to 2025
–
BLRD VA I01 BX002745NIA NIH HHS T32 AG052354NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

Traumatic brain injury (TBI) causes cellular and molecular alterations that contribute to neuropsychiatric disease and epilepsy. GABAergic dysfunction figures prominently in the pathophysiology of TBI, yet the effects of TBI on tonic inhibition in hippocampus remain uncertain. We used a mouse model of severe TBI [controlled cortical impact (CCI)] to investigate GABAergic signaling in dentate gyrus granule cells (DGGCs). Basal tonic GABA currents were not affected by CCI. However, tonic currents induced by the δ subunit-selective GABA

Indexed as

Brain Injuries, TraumaticDentate GyrusAnimalsgamma-Aminobutyric AcidMiceNeuronsReceptors, GABA-Agamma-Aminobutyric AcidReceptors, GABA-AepilepsyGABAA receptorGABAB receptorhippocampusTBItonic inhibition

Identifiers

PMID33514602
PMCPMC8116114
OpenAlexW3121736477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.