Evidence map›Paper›PMID 33514540›Full record

ArticleScience advances2021

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.

Maria Litovchenko, Antonio C A Meireles-Filho, Michael V Frochaux, Roel P J Bevers, Alessio Prunotto, Ane Martin Anduaga, Brian Hollis, Vincent Gardeux, Virginie S Braman, Julie M C Russeil and 3 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Circadian Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Article
  12. Time-restricted feeding regulates lipid metabolism under metabolic challenges.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Review
  13. Viruses in LaboratoryViruses · 2023
    Article
  14. Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Time series transcriptome analysis implicates the circadian clock in theProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Network-based approaches for modeling disease regulation and progression.Computational and structural biotechnology journal · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Maria LitovchenkoSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0003-1868-4933
Antonio C A Meireles-FilhoSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0001-5853-9197
Michael V FrochauxSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0002-4347-5562
Roel P J BeversSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0002-2053-4873
Alessio PrunottoSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0002-6425-964X
Ane Martin AnduagaDepartment of Biology, Brandeis University, Waltham, MA 02453, USA.ORCID 0000-0003-2447-2195
Brian HollisSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.
Vincent GardeuxSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0001-8954-2161
Virginie S BramanSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.
Julie M C RusseilSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0002-0880-9483
Sebastian KadenerDepartment of Biology, Brandeis University, Waltham, MA 02453, USA.
Matteo Dal PeraroSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland.ORCID 0000-0002-2973-3975
Bart DeplanckeSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud 1015, Switzerland. bart.deplancke@epfl.ch.ORCID 0000-0001-9935-843X
SIB Swiss Institute of Bioinformatics · CHBrandeis University · US

Funding

Characterizing a new role for timeless in the generation of robust and plastic circadian rhythmsR01GM125859 · NIGMS · BRANDEIS UNIVERSITY · PI KADENER, SEBASTIAN · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM125859
6 · The paper itself

Abstract

Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of

Indexed as

Circadian ClocksDrosophila ProteinsAnimalsCircadian RhythmDrosophilaDrosophila melanogasterDrosophila Proteins

Identifiers

PMID33514540
PMCPMC7846174
OpenAlexW3123521443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.