ArticleHeart (British Cardiac Society)2021
Contrast-enhanced computed tomography assessment of aortic stenosis.
Article in Heart (British Cardiac Society), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
- Manufacturing 3D aortic root models for in vitro assessment of calcific aortic valve stenosis.Annals of biomedical engineering · 2026Article
- DCFFNet: A New Dual-channel Cross-Feature Fusion Net for Evaluating the Degree of Aortic Valve Calcification Based on Echocardiographic Images.Journal of imaging informatics in medicine · 2026Article
- The potential role of sex related differences of the microbiome and its impact on calcific aortic stenosis: a narrative review.Biology of sex differences · 2026Review
- Sex-Specific Prognostic Value of Aortic Valve Calcium and the Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis (MESA).Circulation. Cardiovascular imaging · 2026Article
- Indexed Aortic Valve Calcium Volume by Computed Tomography Angiography in Patients With Aortic Stenosis: Results of an International Multicenter Cohort Study.JACC. Cardiovascular imaging · 2026Observational
- Severe Trileaflet Aortic Stenosis Without Significant Valve Calcification in an Older Adult.Methodist DeBakey cardiovascular journal · 2026Article
- Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis.Journal of the American Heart Association · 2025Article
- Deciphering the Enigma of Calcific Aortic Valve Disease: The Pivotal Role of Animal Models in Unraveling Pathogenesis and Advancing Therapeutic Strategies.Biomedicines · 2025Review
- Characterization of Aortic Valve Stenosis by CT Angiography in a Diverse US Cohort.Circulation. Cardiovascular imaging · 2025Article
- Aortic Stenosis: Time for a Sex-Based Approach?Journal of clinical medicine · 2025Review
- Association of aortic valve size with the degree of aortic valve calcification in severe high-gradient aortic stenosis.European heart journal. Cardiovascular Imaging · 2025Article
- The impact of intravenous iodinated contrast agents on radiotherapy dose calculation and radiobiological effect predictions in central lung cancer.Frontiers in oncology · 2025Article
- Aortic Valve Calcium: A Narrative Review of its Role in the Assessment of Aortic Stenosis and as a Predictor of Post-transcatheter Aortic Valve Implantation Outcomes.Interventional cardiology (London, England) · 2025Review
- Sex-related disparities in aortic stenosis from disease awareness to treatment: a state-of-the-art review.Journal of thoracic disease · 2024Review
- Grading of Aortic Valve Calcification Severity and Risk Stratification in Aortic Stenosis.Journal of the American Heart Association · 2024Article
- Quantification of Aortic Valve Fibrotic and Calcific Tissue from CTA: Prospective Comparison with Histology.Radiology · 2024Article
- Sex Differences in Aortic Stenosis: From the Pathophysiology to the Intervention, Current Challenges, and Future Perspectives.Journal of clinical medicine · 2024Review
- Aortic Valve Calcium Score: Applications in Clinical Practice and Scientific Research-A Narrative Review.Journal of clinical medicine · 2024Review
- Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies.Annals of medicine and surgery (2012) · 2024Review
- Regional assessment of aortic valve calcification using topographic maps in contrast-enhanced CT:Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 6 countries.
Funding
Abstract
objectivesNon-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in aortic stenosis. We assessed aortic valve calcific and non-calcific disease using contrast-enhanced CT.
methodsThis was a post hoc analysis of 164 patients (median age 71 (IQR 66-77) years, 78% male) with aortic stenosis (41 mild, 89 moderate, 34 severe; 7% bicuspid) who underwent echocardiography and contrast-enhanced CT as part of imaging studies. Calcific and non-calcific (fibrosis) valve tissue volumes were quantified and indexed to annulus area, using Hounsfield unit thresholds calibrated against blood pool radiodensity. The fibrocalcific ratio assessed the relative contributions of valve fibrosis and calcification. The fibrocalcific volume (sum of indexed non-calcific and calcific volumes) was compared with aortic valve peak velocity and, in a subgroup, histology and valve weight.
resultsContrast-enhanced CT calcium volumes correlated with CT calcium score (r=0.80, p<0.001) and peak aortic jet velocity (r=0.55, p<0.001). The fibrocalcific ratio decreased with increasing aortic stenosis severity (mild: 1.29 (0.98-2.38), moderate: 0.87 (1.48-1.72), severe: 0.47 (0.33-0.78), p<0.001) while the fibrocalcific volume increased (mild: 109 (75-150), moderate: 191 (117-253), severe: 274 (213-344) mm
conclusionsContrast-enhanced CT assessment of aortic valve calcific and non-calcific volumes correlates with aortic stenosis severity and may be preferable to non-contrast CT when fibrosis is a significant contributor to valve obstruction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.