Evidence map›Paper›PMID 33514323›Full record

ArticleBMC infectious diseases2021

Atypical presentations of coronavirus disease 2019 (COVID-19) from onset to readmission.

Zhiqi Yang, Xiaofeng Chen, Ruibin Huang, Shengkai Li, Daiying Lin, Zhijian Yang, Hongfu Sun, Guorui Liu, Jinming Qiu, Yanyan Tang and 6 more

Abstract readMulticenter Study
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Clinical Characteristics and Outcome of Readmitted Adult Patients With Acute COVID-19 Infection Within 30 Days of Their Hospital Discharge.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhiqi Yang *Department of Radiology, Meizhou People's Hospital, Meizhou, Guangdong, 514031, People's Republic of China.
Xiaofeng Chen *Department of Radiology, Meizhou People's Hospital, Meizhou, Guangdong, 514031, People's Republic of China.
Ruibin Huang *Department of Radiology, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.
Shengkai LiDepartment of Radiology, Huizhou Municipal Central Hospital, Huizhou, 516001, Guangdong, China.
Daiying LinDepartment of Radiology, Shantou Central Hospital, Shantou, Guangdong, 515041, People's Republic of China.
Zhijian YangDepartment of Radiology, Yongzhou People's Hospital, Yongzhou, Hunan, 425006, People's Republic of China.
Hongfu SunSchool of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, 4072, Australia.
Guorui LiuDepartment of Radiology, 2nd Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515000, People's Republic of China.
Jinming QiuDepartment of Radiology, 2nd Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515000, People's Republic of China.
Yanyan TangDepartment of Radiology, 2nd Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515000, People's Republic of China.
Jianning XiaoDepartment of Radiology, Shantou Central Hospital, Shantou, Guangdong, 515041, People's Republic of China.
Yuting LiaoGE Healthcare, Guangzhou, 510623, China.
Xianheng WuDepartment of Radiology, Shantou Central Hospital, Shantou, Guangdong, 515041, People's Republic of China.
Renhua WuDepartment of Radiology, 2nd Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515000, People's Republic of China.
Xiangguang ChenDepartment of Radiology, Meizhou People's Hospital, Meizhou, Guangdong, 514031, People's Republic of China. cxg966504@163.com.
Zhuozhi DaiDepartment of Radiology, 2nd Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515000, People's Republic of China. zhuozhi@ualberta.ca.ORCID http://orcid.org/0000-0001-8971-8681

Funding

2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant 2020LKSFG06CDepartment of Education of Guangdong Province 2020KZDZX1085Natural Science Foundation of China 81471730Natural Science Foundation of Guangdong Province 2018A030307057
6 · The paper itself

Abstract

backgroundTo investigate the CT imaging and clinical features of three atypical presentations of coronavirus disease 2019 (COVID-19), namely (1) asymptomatic, (2) CT imaging-negative, and (3) re-detectable positive (RP), during all disease stages.

methodsA consecutive cohort of 79 COVID-19 patients was retrospectively recruited from five independent institutions. For each presentation type, all patients were classified into atypical vs. typical groups (i.e., asymptomatic vs.symptomatic, CT imaging-negative vs. CT imaging-positive, and RP and non-RP,respectively). The chi-square test, Student's t test, and Kruskal-Wallis H test were performed to compare CT imaging and clinical features of atypical vs. typical patients for all three presentation categories.

resultsIn our COVID-19 cohort, we found 12.7% asymptomatic patients, 13.9% CT imaging-negative patients, and 8.9% RP patients. The asymptomatic patients had fewer hospitalization days (P=0.043), lower total scores for bilateral lung involvement (P< 0.001), and fewer ground-glass opacities (GGOs) in the peripheral area (P< 0.001) than symptomatic patients. The CT imaging-negative patients were younger (P=0.002), had a higher lymphocyte count (P=0.038), had a higher lymphocyte rate (P=0.008), and had more asymptomatic infections (P=0.002) than the CT imaging-positive patients. The RP patients with moderate COVID-19 had lower total scores of for bilateral lung involvement (P=0.030) and a smaller portion of the left lung affected (P=0.024) than non-RP patients. Compared to their first hospitalization, RP patients had a shorter hospitalization period (P< 0.001) and fewer days from the onset of illness to last RNA negative conversion (P< 0.001) at readmission.

conclusionsSignificant CT imaging and clinical feature differences were found between atypical and typical COVID-19 patients for all three atypical presentation categories investigated in this study, which may help provide complementary information for the effective management of COVID-19.

Indexed as

Radiography, ThoracicTomography, X-Ray ComputedAdultAsymptomatic InfectionsChinaCOVID-19FemaleHospitalizationHumansLungMaleMiddle AgedPatient ReadmissionRetrospective StudiesSARS-CoV-2AsymptomaticCOVID-19CT imaging negativeFeaturesRe-detectable positive

Identifiers

PMID33514323
PMCPMC7844102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.