Evidence map›Paper›PMID 33514051›Full record

ArticlePolymers2021

Electrospinning Fabrication and Cytocompatibility Investigation of Nanodiamond Particles-Gelatin Fibrous Tubular Scaffolds for Nerve Regeneration.

Elena Olăreț, Diana-Maria Drăgușin, Andrada Serafim, Adriana Lungu, Aida Șelaru, Alexandra Dobranici, Sorina Dinescu, Marieta Costache, Iulian Boerașu, Bogdan Ștefan Vasile and 3 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Elena OlărețAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0001-9593-6140
Diana-Maria DrăgușinAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Andrada SerafimAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Adriana LunguAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Aida ȘelaruDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0001-8587-1574
Alexandra DobraniciDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.
Sorina DinescuDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0001-7196-1712
Marieta CostacheDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.
Iulian BoerașuNational Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Bogdan Ștefan VasileNational Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania.ORCID 0000-0002-2267-6453
Doris Steinmüller-NethlDiaCoating. GmbH, 6112 Wattens, Austria.
Horia IovuAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Izabela-Cristina StancuAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-0685-3947
Universitatea Națională de Știință și Tehnologie Politehnica București · ROUniversity of Bucharest · RO

Funding

European Regional Development Fund through Competitiveness Operational Program 2014-2020 P_36_611, MySMIS code 107066Romanian Ministry of Education and Research, CNCS - UEFISCDI PN-III-P1-1.1-TE-2019-0787Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI PN-III-P1-1.2-PCCDI-2017-0782/REGMED - project 2 NERVE
6 · The paper itself

Abstract

This paper reports the electrospinning fabrication of flexible nanostructured tubular scaffolds, based on fish gelatin (FG) and nanodiamond nanoparticles (NDs), and their cytocompatibility with murine neural stem cells. The effects of both nanofiller and protein concentration on the scaffold morphology, aqueous affinity, size modification at rehydration, and degradation are assessed. Our findings indicate that nanostructuring with low amounts of NDs may modify the fiber properties, including a certain regional parallel orientation of fiber segments. NE-4C cells form dense clusters that strongly adhere to the surface of FG50-based scaffolds, while also increasing FG concentration and adding NDs favor cellular infiltration into the flexible fibrous FG70_NDs nanocomposite. This research illustrates the potential of nanostructured NDs-FG fibers as scaffolds for nerve repair and regeneration. We also emphasize the importance of further understanding the effect of the nanofiller-protein interphase on the microstructure and properties of electrospun fibers and on cell-interactivity.

Indexed as

diamond nanoparticleselectrospun fibersfish gelatinnerve guidance channel

Identifiers

PMID33514051
PMCPMC7865256
OpenAlexW3123910660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.