ArticlePolymers2021
Preparation and Characterization of Ionic Conductive Poly(acrylic Acid)-Based Silicone Hydrogels for Smart Drug Delivery System.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 21 citations in OpenAlex.
- Hydrogel coatings for titanium implants: From smart stimuli-responsive strategies to multimodal bone regeneration.Bioactive materials · 2026Review
- Hydrophobic association and ionic coordination synergistically enhance a multifunctional hydrogel for high-performance wearable strain sensing.Communications chemistry · 2026Article
- Thermosensitive Scattering Hydrogels Based on Triblock Poly-Ethers: A Novel Approach to Solar Radiation Regulation.Polymers · 2023Article
- Effective BMP-2 Release and Mineralization on a Graphene Oxide/Polyvinylpyrrolidone Hydrogel Forming Poly (ε-Caprolactone) Nanofibrous Scaffolds.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we developed a smart drug delivery system that can efficiently deliver the required amounts of drugs using the excellent ion conductivity of poly(acrylic acid) (PAA) and an electrical stimulus. As a result of its having carboxyl groups, PAA hydrogel can be used in drug delivery patches to release drugs by ionic conductivity. However, PAA hydrogel has low durability and poor mechanical properties. The carboxyl group of PAA was combined with a siloxane group of silicone using electron-beam irradiation to easily form a crosslinked structure. The PAA-silicone hydrogel has excellent mechanical properties. Specifically, the tensile strength increased more than 3.5 times. In addition, we observed its cell compatibility using fluorescence staining and CCK-8 assays and found good cell viability. Finally, it was possible to control the drug delivery rate efficiently using the voltage applied to the ion-conductive hydrogel. As the voltage was increased to 3, 5, and 7 V, the amount of drug released was 53, 88, and 96%, respectively. These excellent properties of the PAA-silicone hydrogel can be used not only for whitening or anti-wrinkling cosmetics but also in medical drug-delivery systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.