Evidence map›Paper›PMID 33513990›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Deviation of Trypsin Activity Using Peptide Conformational Imprints.

Kiran Reddy Kanubaddi, Pei-Yu Huang, Ya-Lin Chang, Cheng Hsin Wu, Wei Li, Ranjith Kumar Kankala, Dar-Fu Tai, Chia-Hung Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Integration of Adenylate Kinase 1 with Its Peptide Conformational Imprint.International journal of molecular sciences · 2022
    Article
  2. Article
  3. Applications and Properties of Magnetic Nanoparticles.Nanomaterials (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kiran Reddy KanubaddiDepartment of Life Science, National Dong Hwa University, Hualien 97401, Taiwan.
Pei-Yu HuangDepartment of Chemistry, National Dong-Hwa University, Hualien 97401, Taiwan.
Ya-Lin ChangDepartment of Chemistry, National Dong-Hwa University, Hualien 97401, Taiwan.
Cheng Hsin WuDepartment of Chemistry, National Dong-Hwa University, Hualien 97401, Taiwan.
Wei LiDepartment of Chemistry, National Dong-Hwa University, Hualien 97401, Taiwan.
Ranjith Kumar KankalaDepartment of Life Science, National Dong Hwa University, Hualien 97401, Taiwan.ORCID 0000-0003-4081-9179
Dar-Fu TaiDepartment of Chemistry, National Dong-Hwa University, Hualien 97401, Taiwan.
Chia-Hung LeeDepartment of Life Science, National Dong Hwa University, Hualien 97401, Taiwan.
National Dong Hwa University · TWHuaqiao University · CN

Funding

Ministry of Science and Technology, Taiwan 106-2113-M-259-005
6 · The paper itself

Abstract

In this study, a methodology utilizing peptide conformational imprints (PCIs) as a tool to specifically immobilize porcine pancreatic alpha-trypsin (PPT) at a targeted position is demonstrated. Owing to the fabrication of segment-mediated PCIs on the magnetic particles (PCIMPs), elegant cavities complementary to the PPT structure are constructed. Based on the sequence on targeted PPT, the individual region of the enzyme is trapped with different template-derived PCIMPs to show certain types of inhibition. Upon hydrolysis,

Indexed as

conformational imprintmagnetic particlesmolecularly-imprinted polymersporcine pancreatic trypsinsecondary structure

Identifiers

PMID33513990
PMCPMC7911952
OpenAlexW3121817470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.