Evidence map›Paper›PMID 33513945›Full record

ArticleCancers2021

Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention.

Jaqueline Ramalho Buttura, Monize Nakamoto Provisor Santos, Renan Valieris, Rodrigo Duarte Drummond, Alexandre Defelicibus, João Paulo Lima, Vinicius Fernando Calsavara, Helano Carioca Freitas, Vladmir C Cordeiro de Lima, Thais Fernanda Bartelli and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Jaqueline Ramalho ButturaLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Monize Nakamoto Provisor SantosLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Renan ValierisLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0002-8402-3175
Rodrigo Duarte DrummondLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0002-9000-8115
Alexandre DefelicibusLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0002-3484-6317
João Paulo LimaLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Vinicius Fernando CalsavaraDepartment of Statistics and Epidemiology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Helano Carioca FreitasMedical Oncology Department, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0002-8415-073X
Vladmir C Cordeiro de LimaMedical Oncology Department, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Thais Fernanda BartelliLaboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0002-1373-0112
Marc WiednerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Rafael RosalesDepartment of Mathematics and Computer Science, University of São Paulo, Ribeirão Preto 14049-900, Brazil.
Kenneth John GollobTranslational Immuno-Oncology Group, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0003-4184-3867
Joanna LoizouCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0003-1853-0424
Emmanuel Dias-NetoLaboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0001-5670-8559
Diana Noronha NunesLaboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Israel Tojal da SilvaLaboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0002-4687-1499
AC Camargo Hospital · BRAustrian Academy of Sciences · ATUniversidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 14-26897-0Fundação de Amparo à Pesquisa do Estado de São Paulo 15/19324-6Fundação de Amparo à Pesquisa do Estado de São Paulo 16/11791-7
6 · The paper itself

Abstract

DNA mismatch repair deficiency (dMMR) is associated with the microsatellite instability (MSI) phenotype and leads to increased mutation load, which in turn may impact anti-tumor immune responses and treatment effectiveness. Various mutational signatures directly linked to dMMR have been described for primary cancers. To investigate which mutational signatures are associated with prognosis in gastric cancer, we performed a

Indexed as

DNA mismatch repairgastric cancermutational signatureprognosis

Identifiers

PMID33513945
PMCPMC7866019
OpenAlexW3123334105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.