Evidence map›Paper›PMID 33513878›Full record

ArticleInternational journal of molecular sciences2021

LncRNA

Manabu Ogoyama, Akihide Ohkuchi, Hironori Takahashi, Dongwei Zhao, Shigeki Matsubara, Toshihiro Takizawa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. LncRNA H19 promotes vascular remodeling by inhibiting MFN2.Functional & integrative genomics · 2026
    Article
  2. Review
  3. International journal of molecular sciences · 2026
    Article
  4. H19 and IGF2 imprinting from embryogenesis to oncogenesis.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Frontiers in cellular and infection microbiology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Manabu OgoyamaDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.
Akihide OhkuchiDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.ORCID 0000-0002-8861-1572
Hironori TakahashiDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.ORCID 0000-0003-1652-9438
Dongwei ZhaoDepartment of Molecular Medicine and Anatomy, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, Japan.
Shigeki MatsubaraDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.
Toshihiro TakizawaDepartment of Molecular Medicine and Anatomy, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, Japan.
Jichi Medical University · JPNippon Medical School · JP

Funding

Nippon Medical School The Nippon Medical School Grant-in-Aid for Medical Research (2018) to TTTakeda Science Foundation Takeda Science Foundation (2017) to HTThe Ministry of Education, Culture, Sports, Science (MEXT) and Technology/Japan Society for the Promotion of Science, Japan The Grants-in-Aid for Scientific Research (19K18650 to HT; Nos. 17K11256 and 20K09611 to TT)
6 · The paper itself

Abstract

The invasion of extravillous trophoblast (EVT) cells into the maternal decidua, which plays a crucial role in the establishment of a successful pregnancy, is highly orchestrated by a complex array of regulatory mechanisms. Non-coding RNAs (ncRNAs) that fine-tune gene expression at epigenetic, transcriptional, and post-transcriptional levels are involved in the regulatory mechanisms of EVT cell invasion. However, little is known about the characteristic features of EVT-associated ncRNAs. To elucidate the gene expression profiles of both coding and non-coding transcripts (i.e., mRNAs, long non-coding RNAs (lncRNAs), and microRNAs (miRNAs)) expressed in EVT cells, we performed RNA sequencing analysis of EVT cells isolated from first-trimester placentae. RNA sequencing analysis demonstrated that the lncRNA

Indexed as

Cell LineCell MovementCell ProliferationFemaleGATA2 Transcription FactorGene Expression Regulation, DevelopmentalHumansMatrix Metalloproteinase 13Matrix Metalloproteinase 14Matrix MetalloproteinasesMicroRNAsPlacentaPregnancyPregnancy Trimester, FirstRNA, Long NoncodingRNA-SeqGATA2 protein, humanGATA2 Transcription FactorMatrix Metalloproteinase 13Matrix Metalloproteinase 14Matrix MetalloproteinasesMicroRNAsMIRN675 microRNA, humanMMP13 protein, humanMMP14 protein, humanRNA, Long NoncodingRNA, Small Interferingcell invasionextravillous trophoblastGATA2long non-coding RNA H19matrix metalloproteinasemiR-675-5p

Identifiers

PMID33513878
PMCPMC7866107
OpenAlexW3124845802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.