Evidence map›Paper›PMID 33513830›Full record

ArticleInternational journal of molecular sciences2021

Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNFα-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.

Yu-Te Chou, Tze-Tze Liu, Ueng-Cheng Yang, Chia-Chang Huang, Chih-Wei Liu, Shiang-Fen Huang, Tzu-Hao Li, Hsuan-Miao Liu, Ming-Wei Lin, Ying-Ying Yang and 4 more

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Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yu-Te ChouDepartment of Medicine, Taipei Veterans General Hospital, Taipei 11267, Taiwan.
Tze-Tze LiuFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.
Ueng-Cheng YangFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.
Chia-Chang HuangFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.ORCID 0000-0002-1313-4628
Chih-Wei LiuDepartment of Medicine, Taipei Veterans General Hospital, Taipei 11267, Taiwan.
Shiang-Fen HuangFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.
Tzu-Hao LiFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.
Hsuan-Miao LiuGraduate Institute of Traditional Chinese Medicine, Chang Guang Memorial Hospital, Linkou 33371, Taiwan.
Ming-Wei LinFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.
Ying-Ying YangFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.ORCID 0000-0002-7719-0397
Tzung-Yan LeeGraduate Institute of Traditional Chinese Medicine, Chang Guang Memorial Hospital, Linkou 33371, Taiwan.ORCID 0000-0003-4097-2085
Yi-Hsiang HuangDepartment of Medicine, Taipei Veterans General Hospital, Taipei 11267, Taiwan.ORCID 0000-0001-5241-5425
Ming-Chih HouDepartment of Medicine, Taipei Veterans General Hospital, Taipei 11267, Taiwan.
Han-Chieh LinFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11267, Taiwan.
National Yang Ming Chiao Tung University · TWChang Gung Memorial Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 109-2314-B-010-032-MY3Taipei Veterans General Hospital V110-033
6 · The paper itself

Abstract

In advanced cirrhosis, the TNFα-mediated intestinal inflammation and bacteria dysbiosis are involved in the development of inflammation and vasoconstriction-related renal dysfunction. In colitis and acute kidney injury models, activation of SIRT1 attenuates the TNFα-mediated intestinal and renal abnormalities. This study explores the impacts of intestinal SIRT1 deficiency and TNFα-mediated intestinal abnormalities on the development of cirrhosis-related renal dysfunction. Systemic and renal hemodynamics, intestinal dysbiosis [cirrhosis dysbiosis ratio (CDR) as marker of dysbiosis], and direct renal vasoconstrictive response (renal vascular resistance (RVR) and glomerular filtration rate (GFR)) to cumulative doses of TNFα were measured in bile duct ligated (BDL)-cirrhotic ascitic mice. In SIRT1

Indexed as

AnimalsGastrointestinal MicrobiomeGlomerular Filtration RateInflammationIntestinal MucosaIntestinesKidneyLiver CirrhosisMaleMiceMice, Inbred C57BLMice, KnockoutSirtuin 1Tumor Necrosis Factor-alphaUrogenital AbnormalitiesVascular ResistanceSirt1 protein, mouseSirtuin 1Tumor Necrosis Factor-alphacirrhotic ascitesintestinal barrier dysfunctionintestinal dysbiosisNAD-dependent deacetylase sirtuin-1 (SIRT1)renal dysfunctiontumor necrosis factor-α (TNFα)

Identifiers

PMID33513830
PMCPMC7865325
OpenAlexW3122937818

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.