Evidence map›Paper›PMID 33513745›Full record

ReviewCancers2021

The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction.

Pavel Vodicka, Ladislav Andera, Alena Opattova, Ludmila Vodickova

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Precision clinical medicine · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response.International journal of molecular sciences · 2022
    Review
  17. [Advances in research of Musashi2 in solid tumors].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pavel VodickaInstitute of Experimental Medicine, AS CR, 142 20 Prague, Czech Republic.
Ladislav AnderaInstitute of Biotechnology, AS CR, 252 50 Vestec, Czech Republic.
Alena OpattovaInstitute of Experimental Medicine, AS CR, 142 20 Prague, Czech Republic.
Ludmila VodickovaInstitute of Experimental Medicine, AS CR, 142 20 Prague, Czech Republic.
Charles University · CZCzech Academy of Sciences, Institute of Biotechnology · CZ

Funding

Agentura Pro Zdravotnický Výzkum České Republiky NV18-00199Grantová Agentura České Republiky 18-09709SGrantová Agentura České Republiky 19-10543SGrantová Agentura, Univerzita Karlova PROGRES Q 28Grantová Agentura, Univerzita Karlova UNCE/MED/006Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0./0.0/16_019/0000787
6 · The paper itself

Abstract

The disruption of genomic integrity due to the accumulation of various kinds of DNA damage, deficient DNA repair capacity, and telomere shortening constitute the hallmarks of malignant diseases. DNA damage response (DDR) is a signaling network to process DNA damage with importance for both cancer development and chemotherapy outcome. DDR represents the complex events that detect DNA lesions and activate signaling networks (cell cycle checkpoint induction, DNA repair, and induction of cell death).

Indexed as

cancer progressioncancer riskcancer therapyDNA damage responseinteractionstelomere homeostasisTP53 mutational status

Identifiers

PMID33513745
PMCPMC7865496
OpenAlexW3121397224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.