Evidence map›Paper›PMID 33513276›Full record

ArticleMolecular oncology2021

Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma.

Jingtao Chen, Jiefeng Yang, Huan Li, Zhongyuan Yang, Xing Zhang, Xiyuan Li, Jia Wang, Ying Zhang, Shuwei Chen, Ming Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Multi-omics exploration of CAV1Discover oncology · 2025
    Article
  5. Salivary biomarkers: a promising approach for predicting immunotherapy response in head and neck cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  6. TcEVdb: a database for T-cell-derived small extracellular vesicles from single-cell transcriptomes.Database : the journal of biological databases and curation · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Application of single-cell RNA sequencing in head and neck squamous cell carcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jingtao ChenDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jiefeng YangState Key Laboratory of Oncology in South China, Guangzhou, China.
Huan LiState Key Laboratory of Oncology in South China, Guangzhou, China.
Zhongyuan YangDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xing ZhangDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiyuan LiDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jia WangDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Ying ZhangDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Shuwei ChenDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Ming SongDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID 0000-0001-7495-5895
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systematic analysis of tumor-infiltrating lymphocytes is essential for the development of new cancer treatments and the prediction of clinical responses to immunotherapy. Immunomodulatory drugs are used for the treatment of oral squamous cell carcinoma (OSCC), depending on immune infiltration profiles of the tumor microenvironment. In this study, we isolated 11,866 single T cells from tumors and paired adjacent normal tissues of three patients with OSCC. Using single-cell RNA sequencing, we identified 14 distinct T-cell subpopulations within the tumors and 5 T-cell subpopulations in the adjacent normal tissues and delineated their developmental trajectories. Exhausted CD8

Indexed as

Carcinoma, Squamous CellCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCTLA-4 AntigenFemaleForkhead Transcription FactorsHigh Mobility Group ProteinsHumansLymphocytes, Tumor-InfiltratingMaleMouth NeoplasmsPositive Regulatory Domain I-Binding Factor 1Programmed Cell Death 1 ReceptorSingle-Cell AnalysisTranscriptomeCTLA-4 AntigenCTLA4 protein, humanForkhead Transcription FactorsFOXP3 protein, humanHigh Mobility Group ProteinsPDCD1 protein, humanPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanProgrammed Cell Death 1 ReceptorTOX protein, humancancer immunologyoral squamous cell carcinomasingle-cell sequencingT-cell exhaustiontumor-infiltrating lymphocytes

Identifiers

PMID33513276
PMCPMC8024729
OpenAlexW3121642246

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.