ArticlePloS one2021
Exploration of metabolite profiles in the biofluids of dairy cows by proton nuclear magnetic resonance analysis.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Applications of metabolomics in cow health assessment.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Fecal metabolomics to understand intestinal dysfunction in male dairy beef calves at arrival to the rearing farm.Scientific reports · 2025Article
- Functionalized Graphene-Based Biosensors for Early Detection of Subclinical Ketosis in Dairy Cows.ACS applied materials & interfaces · 2024Article
- Spontaneous Oxidation of Organic Matter and Ammonium Uptake from Manure Wastewater by Redox-Active Materials.ACS energy letters · 2024Article
- Metataxonomic and metabolomic profiling revealed Pinus koraiensis cone essential oil reduced methane emission through affecting ruminal microbial interactions and host-microbial metabolism.Animal microbiome · 2024Article
- Microbiome and metabolome analyses of milk and feces from dairy cows with healthy, subclinical, and clinical mastitis.Frontiers in microbiology · 2024Article
- Article
- Ruminal and feces metabolites associated with feed efficiency, water intake and methane emission in Nelore bulls.Scientific reports · 2023Article
- Metabolomic Analysis of Multiple Biological Specimens (Feces, Serum, and Urine) byAnimals : an open access journal from MDPI · 2023Article
- Genes and models for estimating genetic parameters for heat tolerance in dairy cattle.Frontiers in genetics · 2023Review
- Comparison of metabolites in rumen fluid, urine, and feces of dairy cow from subacute ruminal acidosis model measured by proton nuclear magnetic resonance spectroscopy.Animal bioscience · 2023Article
- Exploration of urinary metabolite dynamicity for early detection of pregnancy in water buffaloes.Scientific reports · 2022Article
- Metabolic profiling of serum and urine in lactating dairy cows affected by subclinical ketosis using proton nuclear magnetic resonance spectroscopy.Journal of animal science and technology · 2022Article
- Modulation of Fecal Metabolites by Heat Stress and Diet, and Their Association with Inflammation and Leaky Gut Markers in Dairy Cows.Metabolites · 2022Article
- Metabolomics Analysis Across Multiple Biofluids Reveals the Metabolic Responses of Lactating Holstein Dairy Cows to Fermented Soybean Meal Replacement.Frontiers in veterinary science · 2022Article
- Preliminary demonstration of benchtop NMR metabolic profiling of feline urine: chronic kidney disease as a case study.BMC research notes · 2021Article
- Metabolic Profiling of Rumen Fluid and Milk in Lactating Dairy Cattle Influenced by Subclinical Ketosis Using Proton Nuclear Magnetic Resonance Spectroscopy.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies that screen for metabolites produced in ruminants are actively underway. We aimed to evaluate the metabolic profiles of five biofluids (ruminal fluid, serum, milk, urine, and feces) in dairy cow by using proton nuclear magnetic resonance (1H-NMR) and provide a list of metabolites in each biofluid for the benefit of future research. We analyzed the metabolites in five biofluids from lactating cows using proton nuclear magnetic resonance imaging; 96, 73, 88, 118, and 128 metabolites were identified in the five biofluids, respectively. In addition, 8, 6, 9, and 17 metabolites were unique to ruminal fluid, serum, milk, and urine, respectively. The metabolites present at high concentrations were: acetate, propionate, and butyrate in ruminal fluid; lactate, glucose, and acetate in serum; and lactose, guanidoacetate, and glucitol in milk. In addition, the following metabolites were present at high concentrations: hippurate, urea, and trimethylamine N-oxide in urine and acetate, propionate, and butyrate in feces. The score plots of the principal component analysis did not show clear distinctions among the five biofluid samples. The purpose of this study was to verify the ability of our metabolomics approaches to identify metabolites in the biofluids of dairy cows.
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Registered trials
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