Evidence map›Paper›PMID 33512809›Full record

Observational studyClinical and translational gastroenterology2020

Depressed Colorectal Cancer: A New Paradigm in Early Colorectal Cancer.

Shin-Ei Kudo, Yuta Kouyama, Yushi Ogawa, Katsuro Ichimasa, Tsuyoshi Hamada, Kazuki Kato, Koki Kudo, Takaaki Masuda, Hajime Otsu, Masashi Misawa and 16 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical and translational gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Modeling colorectal cancer evolution.Journal of human genetics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 2 countries.

Shin-Ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yuta KouyamaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yushi OgawaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Katsuro IchimasaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Tsuyoshi HamadaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kazuki KatoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Koki KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Takaaki MasudaKyushu University Beppu Hospital, Beppu, Japan.
Hajime OtsuKyushu University Beppu Hospital, Beppu, Japan.
Masashi MisawaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yuichi MoriDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Toyoki KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Takemasa HayashiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Kunihiko WakamuraDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Hideyuki MiyachiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Naruhiko SawadaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Toshiro SatoDepartment of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Tatsuhiro ShibataDivision of Cancer Genomics, National Cancer Center Research Institute and Laboratory of Molecular Medicine, Tokyo, Japan.
Shigeharu HamataniDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Tetsuo NemotoDepartment of Pathology, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Atsushi NiidaDepartment of Pathology, The Jilei University School of Medicine, Tokyo, Japan.
Satoru MiyanoDivision of Health Medical Computational Science, Health Intelligence Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Masanobu OshimaDivision of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Shuji OginoProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Koshi MimoriKyushu University Beppu Hospital, Beppu, Japan.
Showa University Northern Yokohama Hospital · JPKyushu University Beppu Hospital · JPJikei University School of Medicine · JPThe University of Tokyo · JPHarvard University · USKanazawa University · JPKeio University · JP

Funding

Accelerating Transdisciplinary Epidemiology of Colorectal CancerR35CA197735 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2015 to 2021
$6.0M
Integrating diet, lifestyle and tumor tissue molecular subtyping to study the role of adolescent calcium intake on the risk of early onset colorectal neoplasiaR21CA230873 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI OGINO, SHUJI, WU, KANA · 2018 to 2019
$427k
NCI NIH HHS R21 CA230873NCI NIH HHS R35 CA197735
6 · The paper itself

Abstract

introductionIn contrast to most colorectal carcinomas arising from pedunculated or sessile protruded adenomas, submucosal-invasive (pT1) colorectal carcinoma exhibiting a depressed surface (hereinafter, "depressed colorectal carcinoma," identified by means of high-definition endoscopy) is considered to be derived from depressed precursors. We hypothesized that depressed colorectal neoplasms have unique clinicopathological features different that are different from those of protruded and flat colorectal neoplasms.

methodsWe classified 27,129 colorectal neoplasms (909 pT1 carcinomas and 26,220 adenomas) resected between 2001 and 2017 into depressed (211 carcinomas and 109 adenomas), flat (304 carcinomas and 11,246 adenomas), and protruded subtypes (394 carcinomas and 14,865 adenomas) and compared their clinicopathological features. As exploratory analyses of pT1 carcinomas, we conducted whole-exome sequencing for 19 depressed and 8 protruded subtypes and RNA sequencing for 8 depressed and 8 protruded subtypes.

resultspT1 carcinomas were more common in depressed lesions (66%) than in protruded (2.6%) and flat lesions (2.6%) (P < 0.001). Compared with nondepressed pT1 carcinomas, depressed pT1 carcinomas were positively correlated with lymphovascular invasion, tumor budding, and massive submucosal invasion and inversely correlated with the presence of an adenoma component (all P < 0.001). Depressed adenomas were more likely to contain high-grade dysplasia than nondepressed adenomas (49% vs 11%, P < 0.001). A KRAS mutation was observed only in one of the 19 depressed pT1 carcinomas. Relative to protruded carcinomas, depressed carcinomas generally exhibited higher expression of genes related to angiogenesis and epithelial-mesenchymal transition. DISCUSSION: Depressed colorectal neoplasms may harbor a unique combination of malignant histopathological phenotypes and molecular features.

Indexed as

AdenomaAgedBiomarkers, TumorCarcinomaColonColonoscopyColorectal NeoplasmsDiagnosis, DifferentialDNA Mutational AnalysisEpithelial-Mesenchymal TransitionExome SequencingFemaleGene Expression Regulation, NeoplasticHumansIntestinal MucosaMaleBiomarkers, TumorKRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID33512809
PMCPMC7732270
OpenAlexW3110704782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.