Evidence map›Paper›PMID 33512573›Full record

ArticleApplied microbiology and biotechnology2021

Metabolic engineering of Zymomonas moblis for ethylene production from straw hydrolysate.

Yan He, Bo Wu, Wei Xia, Kun-Yang Zhao, Yao Qin, Qiong Tan, Qin-Hui Yu, Pan-Ting Liu, Guo-Quan Hu, Ming-Xiong He

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. S267P mutation of OxyR regulator inSynthetic and systems biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yan He *Biomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China.
Bo Wu *Biomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China.
Wei XiaInstitute of Ecological Environment, Chengdu University of Technology, No. 1, East Third Road, Erxian Bridge, Chenghua District, Chengdu, 610059, China.
Kun-Yang ZhaoBiomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China.
Yao QinCollege of Pharmacy and Biological Engineering, Chengdu University, No. 2025, Cheng Luo Road, Chengdu, 610106, China.
Qiong TanBiomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China.
Qin-Hui YuCollege of Pharmacy and Biological Engineering, Chengdu University, No. 2025, Cheng Luo Road, Chengdu, 610106, China.
Pan-Ting LiuBiomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China.
Guo-Quan HuBiomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China.
Ming-Xiong HeBiomass Energy Technology Research Centre, Key Laboratory of Development and Application of Rural Renewable Energy (Ministry of Agriculture and Rural Affairs), Biogas Institute of Ministry of Agriculture and Rural Affairs, Section 4-13, Renmin Rd. South, Chengdu, 610041, China. hemingxiong@caas.cn.ORCID http://orcid.org/0000-0002-9780-6865
Biogas Institute of Ministry of Agriculture · CNChengdu University · CNChengdu University of Technology · CNNational Institute of Measurement and Testing Technology · CN

Funding

Central Public-interest Scientific Institution Basal Research Fund Y2019XK23-01the National Natural Sciences Foundation of China 32070036
6 · The paper itself

Abstract

Biological ethylene production is a promising sustainable alternative approach for fossil-based ethylene production. The high glucose utilization of Z. mobilis makes it as a promising bioethylene producer. In this study, Zymomonas mobilis has been engineered to produce ethylene through the introduction of the synthetic ethylene-forming enzyme (EFE). We also investigated the effect of systematically knocking out the competitive metabolic pathway of pyruvate in an effort to improve the availability of pyruvate for ethylene production in Z. mobilis expressing EFE. Guided by these results, we tested a number of conjectures that could improve the α-ketoglutarate supply. Optimization of these pathways and different substrate supplies resulted in a greater production of ethylene (from 1.36 to 12.83 nmol/OD

Indexed as

ZymomonasBiomassEthylenesMetabolic EngineeringZea maysEthylenesEthyleneEthylene-forming enzymeLignocellulosic biomassZymomonas mobliisα-Ketoglutarate

Identifiers

PMID33512573
OpenAlexW3125650625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.