ArticleSocial cognitive and affective neuroscience2021
Left superior temporal sulcus morphometry mediates the impact of anxiety and depressive symptoms on sleep quality in healthy adults.
Article in Social cognitive and affective neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
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- Subtypes of Insomnia Disorder Identified by Cortical Morphometric Similarity Network.Human brain mapping · 2025Article
- Multiple voxel pattern analysis shows associations between chronic fatigue syndrome and cortical atrophy.Frontiers in neuroscience · 2025Article
- A review on anxiety and sleep.Bioinformation · 2025Article
- Distinct effect of partial sleep deprivation associated with gray matter changes in young and old adults.Frontiers in aging neuroscience · 2025Article
- Effects of childhood trauma on sustained attention in major depressive disorder: the mediating role of brain activity and functional connectivity.BMC psychiatry · 2024Article
- Stress and Psychosocial Distress Scale with Blunted Oscillatory Dynamics Serving Abstract Reasoning.Depression and anxiety · 2024Article
- Article
- Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Pandemic Anxiety Inventory: A validation study.Journal of health psychology · 2023Article
- Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson's Disease in Early-Stage.Frontiers in aging neuroscience · 2021Article
- Oscillatory network markers of subcallosal cingulate deep brain stimulation for depression.Brain stimulationArticle
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety and depressive symptoms may predispose individuals to sleep disturbance. Understanding how these emotional symptoms affect sleep quality, especially the underlying neural basis, could support the development of effective treatment. The aims of the present study were therefore to investigate potential changes in brain morphometry associated with poor sleep quality and whether this structure played a mediating role between the emotional symptoms and sleep quality. One hundred and forty-one healthy adults (69 women, mean age = 26.06 years, SD = 6.36 years) were recruited. A structural magnetic resonance imaging investigation was performed, and self-reported measures of anxiety, depressive symptoms and sleep quality were obtained for each participant. Whole-brain regression analysis revealed that worse sleep quality was associated with thinner cortex in left superior temporal sulcus (STS). Furthermore, the thickness of left STS mediated the association between the emotional symptoms and sleep quality. A subsequent commonality analysis showed that physiological component of the depressive symptoms had the greatest influence on sleep quality. In conclusion, thinner cortex in left STS may represent a neural substrate for the association between anxiety and depressive symptoms and poor sleep quality and may thus serve as a potential target for neuromodulatory treatment of sleep problems.
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