ArticleBlood2021
Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma.
Article in Blood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 82 citations in OpenAlex.
- Clinical pathological features and prognosis of diffuse large B-cell lymphoma initially diagnosed by bone marrow biopsy in patients presenting with peripheral blood cytopenia.Virchows Archiv : an international journal of pathology · 2026Article
- Histologic Diagnosis of Intravascular Large B-Cell Lymphoma After Endovascular Thrombectomy: A Case Report of a Rare and Incidental Finding.Reports (MDPI) · 2026Article
- Breaking diagnostic and therapeutic barriers in intravascular large B-cell lymphoma: A 13-year real-world study from China.Orphanet journal of rare diseases · 2026Article
- The prognostic and clinical utility of circulating tumor DNA in diffuse large B-cell lymphoma: a systematic review and meta-analysis.NPJ precision oncology · 2025Review
- Recent advances in understanding and management of intravascular large B-cell lymphoma.Japanese journal of clinical oncology · 2025Review
- Clinicopathological, Genomic, and Transcriptomic Feature Analysis of Primary Adrenal Large B-cell Lymphoma: Insights Into Immune-privileged Sites.The American journal of surgical pathology · 2025Article
- [Recurrent fever, persistent cytopenia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Case Report: Neuropsychological Profile of a Patient With Intravascular Large B-Cell Lymphoma Following Infection and Vaccination.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Review
- Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review.Journal of Zhejiang University. Science. B · 2025Review
- A Rare Case of Adrenal Intravascular Large B-Cell Lymphoma Diagnosed via Percutaneous Needle Biopsy.World journal of surgical oncology · 2025Article
- Simultaneous intravascular large B‑cell lymphoma and papillary thyroid carcinoma: A case report.Molecular and clinical oncology · 2025Article
- Article
- Spheroid culture to select theoretical therapeutic drugs in intravascular large B-cell lymphoma.Cancer science · 2025Article
- Prognostic factors of patients with intravascular large B cell lymphoma: a multicenter study in China.Frontiers in oncology · 2025Article
- A case report and literature review of a rare lymphoma with repeated fever by pain and numbness in both lower limbs.Frontiers in medicine · 2025Article
- Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review.Frontiers in oncology · 2025Article
- In the era of targeted therapy and immunotherapy: advances in the treatment of large B-cell lymphoma of immune-privileged sites.Frontiers in immunology · 2025Review
- Primary pulmonary intravascular large B‑cell lymphoma: Indications from cytomorphology findings through CT‑guided puncture: A case report.Oncology letters · 2025Article
- Article
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Authors and funding
32 authors at 14 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a unique type of extranodal lymphoma characterized by selective growth of tumor cells in small vessels without lymphadenopathy. Greater understanding of the molecular pathogenesis of IVLBCL is hampered by the paucity of lymphoma cells in biopsy specimens, creating a limitation in obtaining sufficient tumor materials. To uncover the genetic landscape of IVLBCL, we performed whole-exome sequencing (WES) of 21 patients with IVLBCL using plasma-derived cell-free DNA (cfDNA) (n = 18), patient-derived xenograft tumors (n = 4), and tumor DNA from bone marrow (BM) mononuclear cells (n = 2). The concentration of cfDNA in IVLBCL was significantly higher than that in diffuse large B-cell lymphoma (DLBCL) (P < .0001) and healthy donors (P = .0053), allowing us to perform WES; most mutations detected in BM tumor DNA were successfully captured in cfDNA and xenograft. IVLBCL showed a high frequency of genetic lesions characteristic of activated B-cell-type DLBCL, with the former showing conspicuously higher frequencies (compared with nodal DLBCL) of mutations in MYD88 (57%), CD79B (67%), SETD1B (57%), and HLA-B (57%). We also found that 8 IVLBCL (38%) harbored rearrangements of programmed cell death 1 ligand 1 and 2 (PD-L1/PD-L2) involving the 3' untranslated region; such rearrangements are implicated in immune evasion via PD-L1/PD-L2 overexpression. Our data demonstrate the utility of cfDNA and imply important roles for immune evasion in IVLBCL pathogenesis and PD-1/PD-L1/PD-L2 blockade in therapeutics for IVLBCL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.