Evidence map›Paper›PMID 33512030›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021

Divergent effects of distinct perivascular cell subsets for intra-articular cell therapy in posttraumatic osteoarthritis.

Ginny Ching-Yun Hsu, Masnsen Cherief, Takashi Sono, Yiyun Wang, Stefano Negri, Jiajia Xu, Bruno Peault, Aaron W James

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Ginny Ching-Yun HsuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-5923-3413
Masnsen CheriefDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Takashi SonoDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-5599-0185
Yiyun WangDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-0775-4377
Stefano NegriDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Jiajia XuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Bruno PeaultDepartment of Orthopaedic Surgery, Orthopaedic Hospital, Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, California, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USUniversity of California, Los Angeles · US

Funding

Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
Medical Research Council G1000816NIAMS NIH HHS K08 AR068316NIAMS NIH HHS R01 AR070773NIDCR NIH HHS R21 DE027922NIH HHS S10 OD023548
6 · The paper itself

Abstract

Intra-articular injection of mesenchymal stem cells has shown benefit for the treatment of osteoarthritis (OA). However, mesenchymal stem/stromal cells at the origin of these clinical results are heterogenous cell populations with limited cellular characterization. Here, two transgenic reporter mice were used to examine the differential effects of two precisely defined perivascular cell populations (Pdgfrα

Indexed as

Cartilage, ArticularOsteoarthritisAnimalsCell- and Tissue-Based TherapyDisease Models, AnimalInjections, Intra-ArticularMiceMice, Inbred C57BLMice, TransgenicReceptor, Platelet-Derived Growth Factor alphaSclerosisReceptor, Platelet-Derived Growth Factor alphaadventitial cellcell therapyDMMosteoarthritisPdgfrαPdgfrβsynovium

Identifiers

PMID33512030
PMCPMC8319216
OpenAlexW3126116170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.