ArticleJournal of periodontology2021
Inflammation of the periodontium associates with risk of future cardiovascular events.
Article in Journal of periodontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro data.Cancer metastasis reviews · 2025Pooled it
- Epithelial Inflammatory iNOS-Nitrate Axis EnhancesInternational journal of molecular sciences · 2026Article
- Synergistic Effects of Social Determinants of Health and Periodontitis on Premature Cardiovascular Mortality: A Nationally Representative Cohort Study.Journal of public health dentistry · 2026Article
- LPS-Induced TNF-α and IL-1 Signaling in Periodontitis: Molecular Mechanisms and Therapeutic Opportunities.Current issues in molecular biology · 2026Review
- Development of a Quantitative Detection System forDentistry journal · 2026Article
- Association between periodontitis and cardiovascular disease: a retrospective analysis.BMC oral health · 2026Observational
- Combined Influence of Dental Caries and Periodontal Disease on Ischemic Stroke Risk.Neurology open access · 2025Article
- Trained immunity in chronic inflammatory diseases and cancer.Nature reviews. Immunology · 2025Review
- More than Just a Toothache: Inflammatory Mechanisms Linking Periodontal Disease to Cardiovascular Disease and the Protective Impact of Cardiorespiratory Fitness.Biomedicines · 2025Review
- Periodontitis: Grade Modifiers Revisited.Oral diseases · 2025Review
- High-Frequency Ultrasound Characterization of Periodontal Soft Tissues Pre- and Post-Bacterial Inoculation.Ultrasound in medicine & biology · 2025Article
- Unraveling the Applicability of LbL Coatings for Drug Delivery in Dental Implant-Related Infection Treatment.ACS biomaterials science & engineering · 2025Review
- Addressing disparities in oral health access and outcomes for aging adults in the United States.Frontiers in dental medicine · 2025Review
- Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities.Cardiovascular research · 2024Review
- Age-group-specific association of oral health and systemic health on cognitive function: a cross-sectional study of Korean elders.BMC oral health · 2023Article
- The rosetta stone of successful ageing: does oral health have a role?Biogerontology · 2023Review
- Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study.BMC medicine · 2023Article
- Association between Periodontal Disease and Arteriosclerosis-Related Diseases.Journal of atherosclerosis and thrombosis · 2023Review
- A Novel Piezoelectric-Assisted Non-Surgical Periodontal Treatment: A Prospective Case Series.Dentistry journal · 2023Article
- Peri-implantitis and systemic inflammation: A critical update.The Saudi dental journal · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWhile growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD
methods
resultsThirteen individuals developed MACE during follow-up (median 4.1 years). PD
conclusionPD
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.