ReviewCurrent cardiology reviews2021
Loneliness and Social Isolation: Determinants of Cardiovascular Outcomes.
Review in Current cardiology reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03590327 (Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Are social isolation, lack of social support or loneliness risk factors for cardiovascular disease in Australia and New Zealand? A systematic review and meta-analysis.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2022Pooled it
- A systematic review of loneliness and social isolation scales used in epidemics and pandemics.Psychiatry research · 2021Pooled it
- Strain-Specific Cognitive and Neurobiological Vulnerabilities to Social Isolation in Late Middle-Aged Wistar, Wistar-Kyoto, and Spontaneously Hypertensive Rats.Neurochemical research · 2026Article
- Coronary Artery Disease and Loneliness: A Cross-Sectional Analysis using the Revised UCLA Loneliness Scale.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026Article
- Exploring the association of poor social support and loneliness with cardiovascular history among lebanese residents: insights into myocardial infarction and stroke: a cross-sectional approach.BMC cardiovascular disorders · 2026Article
- Social Isolation Trajectories Spanning Childhood to Adulthood and Mortality Risk in CKM Syndrome: Evidence From CHARLS.Brain and behavior · 2026Article
- Article
- Network analysis of social isolation, loneliness, depression and anxiety among post-discharge rehabilitation patients.Frontiers in psychiatry · 2026Article
- The Emerging Roles of Resolvins: Potential Diagnostic Biomarkers for Cardiovascular Diseases.Current cardiology reviews · 2026Review
- Overindebted, unsupported and lonely, and mentally stressed and depressed-exploring the relationship between overindebtedness, social disconnectedness and poor mental health in a population-based Swiss study.BMC public health · 2025Article
- The less lonely and the more satisfied you are, the merrier is … the heart!European heart journal. Quality of care & clinical outcomes · 2025Article
- Association of loneliness and social isolation with excess risk of cardiovascular events in people with obesity: a prospective cohort study.Journal of global health · 2025Article
- Development and Validation of a Nomogram to Predict Depression Risk in Patients with Cardiovascular Disease.Healthcare (Basel, Switzerland) · 2025Article
- Loneliness and Social Isolation in Individuals with Acute Myocardial Infarction and Takotsubo Syndrome: A Scoping Review.Healthcare (Basel, Switzerland) · 2025Review
- Review
- Association Between Geriatric Oral Health Assessment Index and Cardiovascular Disease in Korean Older Adults.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Topic: Evaluation and Treatment of Social Isolation and Loneliness: Evidence-based Recommendations for Stroke and Neurological Rehabilitation.Current physical medicine and rehabilitation reports · 2025Article
- Social isolation: an integrated molecular web that disrupts cellular homeostasis.Frontiers in neuroscience · 2025Review
- Polygenic risk of social isolation behavior and its influence on psychopathology and personality.Molecular psychiatry · 2024Article
- Social Connection: A Neglected Social Determinant of Health and an Opportunity to Improve Disease Management.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One in three Americans report experiencing loneliness in everyday life, a number that has grown exponentially over the last few decades. As we respond to the SARS-COV2 pandemic with quarantine and social distancing, social isolation and feelings of loneliness are increasing among people of all ages. This presents as an opportune time to recognize the public health impact of these important psychosocial determinants. Loneliness and social isolation are associated with a higher incidence of CVD, higher healthcare utilization and worse outcomes even after controlling for conventional risk factors of CVD. In this review, we discuss loneliness and social isolation as determinants of cardiovascular outcomes, the pathophysiology of this association, and its implications in clinical practice. We discuss some of the shortcomings in the assessment of loneliness and social isolation while identifying the most commonly used rating scales for the same. Finally, we suggest modifications to interventions for loneliness and social isolation during the COVID-19 pandemic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.