Evidence map›Paper›PMID 33511788›Full record

SynthesisESC heart failure2021

Risk of in-hospital life-threatening ventricular arrhythmia or death after ST-elevation myocardial infarction vs. the Takotsubo syndrome.

Rickard Zeijlon, Jasmina Chamat, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Johan Wågerman, Vina Le, Aaron Shekka Espinosa, Erik Nyman, Elmir Omerovic and 1 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Rickard ZeijlonDepartment of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden.ORCID 0000-0001-6422-604X
Jasmina ChamatDepartment of Cardiology, Sahlgrenska University Hospital/Ö, Gothenburg, Sweden.
Israa EnabtawiWallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Sandeep JhaDepartment of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden.
Mohammed Munir MohammedDepartment of Internal Medicine, Norra Älvsborgs Länssjukhus, Trollhättan, Sweden.
Johan WågermanWallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Vina LeWallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Aaron Shekka EspinosaDepartment of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden.
Erik NymanWallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Elmir OmerovicDepartment of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden.
Björn RedforsDepartment of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden.
Sahlgrenska University Hospital · SEWallenberg Wood Science Center · SENewYork–Presbyterian Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe risk of life-threatening ventricular arrhythmias (LTVA) has been reported to be lower in Takotsubo syndrome (TS) compared with ST-elevation myocardial infarction (STEMI). However, the extent to which these differences relate to the fact that most patients with TS are women (who have a lower risk of LTVA) and a relatively larger proportion of patients with STEMI are men is incompletely understood. We aimed to investigate the risk of LTVA or death in sex-matched and age-matched patients with TS, anterior STEMI, and non-anterior STEMI. METHODS AND

resultsWe systematically reviewed the charts of all patients with TS who were treated at Sahlgrenska University Hospital (Gothenburg, Sweden) between 2008 and 2019. A total of 155 patients with confirmed TS (according to the European Society of Cardiology diagnostic criteria for TS) were sex-matched and age-matched 1:1:1 to patients with anterior and non-anterior STEMI. Baseline characteristics and in-hospital outcomes were recorded directly from the patient charts for all patients, and all admission electrocardiographs were analysed. The primary outcome was the composite of death or LTVA [defined as sustained ventricular tachycardia (>30 s) or ventricular fibrillation] within 72 h. The risk of LTVA or death within 72 h after admission was considerably lower in TS (2.6%) vs. anterior STEMI (14%; P = 0.002) and non-anterior STEMI (9.0%; P = 0.02), despite similar or greater risks of acute heart failure, and similar risks of cardiogenic shock. Compared with STEMI, TS was associated with a lower risk of sustained and non-sustained ventricular tachycardia and ventricular fibrillation.

conclusionsIn a predominantly female age-matched and sex-matched cohort of patients with TS, anterior STEMI, and non-anterior STEMI, the adjusted risk of in-hospital LTVA or death was considerably lower in TS compared with STEMI, despite similar or greater risk of acute heart failure and similar risk of cardiogenic shock.

Indexed as

ST Elevation Myocardial InfarctionTakotsubo CardiomyopathyArrhythmias, CardiacFemaleHospitalsHumansMaleSwedenDeathLife-threatening arrhythmiaST-segment elevation myocardial infarctionTakotsuboVentricular arrhythmia

Identifiers

PMID33511788
PMCPMC8006718
OpenAlexW3125021950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.