SynthesisCurrent rheumatology reports2021
Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials.
Synthesis in Current rheumatology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06359665 (A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis), which is not on this map. Cited by 28 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis
Who cites it
28 citing papers in PubMed, 7 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis.Nutrients · 2025Pooled it
- Effect of turmeric products on knee osteoarthritis: a systematic review and network meta-analysis.BMC complementary medicine and therapies · 2025Pooled it
- Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.BMC complementary medicine and therapies · 2025Pooled it
- Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.Frontiers in pharmacology · 2025Pooled it
- Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials.Clinical rheumatology · 2023Pooled it
- Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.BMC complementary medicine and therapies · 2022Pooled it
- Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials.Current rheumatology reports · 2021Pooled it
- Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults: A Randomized, Cross-Over, Clinical Trial.Nutrients · 2026Trial
- Trial
- Ayurveda in Preventive and Supportive Healthcare: Current Evidence, Safety, and Clinical Integration.Cureus · 2026Review
- An investigation into the underlying mechanisms of risperidone-induced antinociception through the cholinergic pathway.Pharmaceutical science advances · 2025Article
- A Scoping Narrative Review of Curcumin in Pain Medicine: The Need for Further Study.Integrative medicine (Encinitas, Calif.) · 2025Review
- A Panoramic Review on the Management of Rheumatoid Arthritis through Herbalism.Current rheumatology reviews · 2025Review
- Role of curcumin in altering gut microbiota for anti-obesity and anti-hyperlipidemic effects.Frontiers in microbiology · 2025Review
- Efficacy ofJournal of rheumatic diseases · 2025Article
- Chemical Composition of Turmeric (Foods (Basel, Switzerland) · 2024Article
- Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model.Scientific reports · 2024Article
- Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Activation of cannabinoid receptor 2 by turmeric oleoresin reduces inflammation and oxidative stress in an osteoarthritisFrontiers in pharmacology · 2024Article
- Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the reviewFinding appropriate pharmacological options to treat osteoarthritis (OA) remain challenging. We aimed to determine the efficacy and safety of all types of turmeric extracts for the management of knee OA. RECENT
findingsSixteen RCTs of up to 16 weeks duration including 1810 adults with knee OA were included. Eleven RCTs compared the efficacy of turmeric extracts with placebo and five with active comparators (NSAIDs). The overall risk bias of included RCTs was moderate. Turmeric extracts significantly reduced knee pain (SMD - 0.82, 95% CI - 1.17 to - 0.47, I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.